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[The role of olanzapine in Parkinsonian dopaminergic psychosis].
Rev Neurol. 2002 Oct 1-15; 35(7):691-6.RN

Abstract

INTRODUCTION

The drug induced psychosis (DIP) that appears in Parkinson s disease (PD) is a frequent complication which is difficult to deal with therapeutically. Treatment is based on lowering the amount of antiparkinson drugs or using classical neuroleptics (haloperidol), which in both cases deteriorates motor function. Recently, antipsychotic drugs have appeared which are called atypical (AA) due to their scarce or null motor effects.

METHOD

We carried out a review of the research work that has been published in which one of these AA, olanzapine (OLZ), was used to treat the DIP that appears in PD patients. The results obtained show OLZ to be an effective antipsychotic drug. However, the data on its capacity to deteriorate motor function is contradictory and it has not been possible to pinpoint the reasons why this adverse side effect appears in some patients and not in others. The causes that have been suggested, although they do not account for all the cases, are the use of high doses of OLZ and the prior existence of dementia. Moreover, some cases of OLZ induced agranulocytosis have been detected, although it was thought that this side effect within the AA was exclusive to clozapine.

CONCLUSION

Although it is effective as an antipsychotic drug, there exists contradictory data about the capacity of OLZ to deteriorate the state of patients suffering from Parkinson s disease, which means that it does not seem to be the first choice drug in the DIP that appears in PD.

Authors+Show Affiliations

Servicio de Neurología, Hospital Universitario Virgen Macarena, Sevilla, España. jaduran@us.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

spa

PubMed ID

12389159

Citation

Durán-Ferreras, E, et al. "[The Role of Olanzapine in Parkinsonian Dopaminergic Psychosis]." Revista De Neurologia, vol. 35, no. 7, 2002, pp. 691-6.
Durán-Ferreras E, Chacón-Peña JR, Durán-Quintana JA. [The role of olanzapine in Parkinsonian dopaminergic psychosis]. Rev Neurol. 2002;35(7):691-6.
Durán-Ferreras, E., Chacón-Peña, J. R., & Durán-Quintana, J. A. (2002). [The role of olanzapine in Parkinsonian dopaminergic psychosis]. Revista De Neurologia, 35(7), 691-6.
Durán-Ferreras E, Chacón-Peña JR, Durán-Quintana JA. [The Role of Olanzapine in Parkinsonian Dopaminergic Psychosis]. Rev Neurol. 2002 Oct 1-15;35(7):691-6. PubMed PMID: 12389159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of olanzapine in Parkinsonian dopaminergic psychosis]. AU - Durán-Ferreras,E, AU - Chacón-Peña,J R, AU - Durán-Quintana,J A, PY - 2002/10/22/pubmed PY - 2003/10/31/medline PY - 2002/10/22/entrez SP - 691 EP - 6 JF - Revista de neurologia JO - Rev Neurol VL - 35 IS - 7 N2 - INTRODUCTION: The drug induced psychosis (DIP) that appears in Parkinson s disease (PD) is a frequent complication which is difficult to deal with therapeutically. Treatment is based on lowering the amount of antiparkinson drugs or using classical neuroleptics (haloperidol), which in both cases deteriorates motor function. Recently, antipsychotic drugs have appeared which are called atypical (AA) due to their scarce or null motor effects. METHOD: We carried out a review of the research work that has been published in which one of these AA, olanzapine (OLZ), was used to treat the DIP that appears in PD patients. The results obtained show OLZ to be an effective antipsychotic drug. However, the data on its capacity to deteriorate motor function is contradictory and it has not been possible to pinpoint the reasons why this adverse side effect appears in some patients and not in others. The causes that have been suggested, although they do not account for all the cases, are the use of high doses of OLZ and the prior existence of dementia. Moreover, some cases of OLZ induced agranulocytosis have been detected, although it was thought that this side effect within the AA was exclusive to clozapine. CONCLUSION: Although it is effective as an antipsychotic drug, there exists contradictory data about the capacity of OLZ to deteriorate the state of patients suffering from Parkinson s disease, which means that it does not seem to be the first choice drug in the DIP that appears in PD. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/12389159/[The_role_of_olanzapine_in_Parkinsonian_dopaminergic_psychosis]_ L2 - http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2002046&Revista=Revneurol DB - PRIME DP - Unbound Medicine ER -