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Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer.
Br J Surg. 2002 Nov; 89(11):1357-69.BJ

Abstract

BACKGROUND

Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited genetic condition associated with microsatellite instability; it accounts for around 5 per cent of all cases of colorectal cancer. This review examines recent data on management strategies for this condition.

METHODS

A Medline-based literature search was performed using the keywords 'HNPCC' and 'microsatellite instability'. Additional original papers were obtained from citations in articles identified by the initial search.

RESULTS AND CONCLUSION

The Amsterdam criteria identify patients in whom the presence of an inherited mutation should be investigated. Those with a mutation should be offered counselling and screening. The role of prophylactic surgery has been superseded by regular colonoscopy, which dramatically reduces the risk of colorectal cancer. Screening for extracolonic malignancy is also advocated, but the benefits are uncertain. Chemoprevention may be of value in lowering the incidence of bowel cancer in affected patients, but further studies are required.

Authors+Show Affiliations

Academic Department of Surgery, University College London, Second Floor, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12390374

Citation

Lawes, D A., et al. "Pathogenesis and Clinical Management of Hereditary Non-polyposis Colorectal Cancer." The British Journal of Surgery, vol. 89, no. 11, 2002, pp. 1357-69.
Lawes DA, SenGupta SB, Boulos PB. Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer. Br J Surg. 2002;89(11):1357-69.
Lawes, D. A., SenGupta, S. B., & Boulos, P. B. (2002). Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer. The British Journal of Surgery, 89(11), 1357-69.
Lawes DA, SenGupta SB, Boulos PB. Pathogenesis and Clinical Management of Hereditary Non-polyposis Colorectal Cancer. Br J Surg. 2002;89(11):1357-69. PubMed PMID: 12390374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer. AU - Lawes,D A, AU - SenGupta,S B, AU - Boulos,P B, PY - 2002/10/23/pubmed PY - 2002/12/3/medline PY - 2002/10/23/entrez SP - 1357 EP - 69 JF - The British journal of surgery JO - Br J Surg VL - 89 IS - 11 N2 - BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited genetic condition associated with microsatellite instability; it accounts for around 5 per cent of all cases of colorectal cancer. This review examines recent data on management strategies for this condition. METHODS: A Medline-based literature search was performed using the keywords 'HNPCC' and 'microsatellite instability'. Additional original papers were obtained from citations in articles identified by the initial search. RESULTS AND CONCLUSION: The Amsterdam criteria identify patients in whom the presence of an inherited mutation should be investigated. Those with a mutation should be offered counselling and screening. The role of prophylactic surgery has been superseded by regular colonoscopy, which dramatically reduces the risk of colorectal cancer. Screening for extracolonic malignancy is also advocated, but the benefits are uncertain. Chemoprevention may be of value in lowering the incidence of bowel cancer in affected patients, but further studies are required. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/12390374/Pathogenesis_and_clinical_management_of_hereditary_non_polyposis_colorectal_cancer_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1323&date=2002&volume=89&issue=11&spage=1357 DB - PRIME DP - Unbound Medicine ER -