Tags

Type your tag names separated by a space and hit enter

Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients.
Liver 2002; 22(5):374-9L

Abstract

PURPOSE

We studied the clinical features and the etiology of hepatitis B virus surface antigen (HBsAg)-negative and antibody to hepatitis C virus (anti-HCV) negative patients with hepatocellular carcinoma.

METHODS

A total of 550 patients, hospitalized with an initial diagnosis of HCC were retrospectively studied. Eighty-one of these patients were HBsAg-positive (HB group), 404 patients were anti-HCV positive (HC group). The other 65 patients were negative for both HBsAg and for anti-HCV (NBNC group). We purified HBV-X gene from HCC or non-tumorous liver tissue of 23 NBNC patients using PCR.

RESULTS

Clinical features of NBNC as compared with HB and HC patients were as follows, respectively: non-cirrhosis rate (%): 57,37,15 (P = 0.02 for HB, P < 0.00001 for HC), the proportion of patients with normal ALT concentrations (%): 59,28,10 (P = 0.0002 for HB, P < 0.00001 for HC). Forty of 59 NBNC patients (68%) had anti-HBs and/or anti-HBc (healthy controls: 29%, P < 0.00001) and two of 56 had serum HBV DNA. Twelve of 23 NBNC patients had HBV-X gene in HCC and/or non-cancerous liver tissues (52%). None of 52 had serum HCV RNA.

CONCLUSIONS

The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue.

Authors+Show Affiliations

Department of Gastroenterology, Saiseikai Kumamoto Hospital, Kumamoto City, 861-4193, Japan. h-yiochi@skh.saiseikai.or.jp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12390472

Citation

Higashi, Yoichiro, et al. "Correlation of Clinical Characteristics With Detection of Hepatitis B Virus X Gene in Liver Tissue in HBsAg-negative, and HCV-negative Hepatocellular Carcinoma Patients." Liver, vol. 22, no. 5, 2002, pp. 374-9.
Higashi Y, Tada S, Miyase S, et al. Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. Liver. 2002;22(5):374-9.
Higashi, Y., Tada, S., Miyase, S., Hirota, K., Imamura, H., Kamio, T., & Suko, H. (2002). Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. Liver, 22(5), pp. 374-9.
Higashi Y, et al. Correlation of Clinical Characteristics With Detection of Hepatitis B Virus X Gene in Liver Tissue in HBsAg-negative, and HCV-negative Hepatocellular Carcinoma Patients. Liver. 2002;22(5):374-9. PubMed PMID: 12390472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. AU - Higashi,Yoichiro, AU - Tada,Shuji, AU - Miyase,Shuichi, AU - Hirota,Kazuhiko, AU - Imamura,Haruo, AU - Kamio,Takihiro, AU - Suko,Hironobu, PY - 2002/10/23/pubmed PY - 2003/4/16/medline PY - 2002/10/23/entrez SP - 374 EP - 9 JF - Liver JO - Liver VL - 22 IS - 5 N2 - PURPOSE: We studied the clinical features and the etiology of hepatitis B virus surface antigen (HBsAg)-negative and antibody to hepatitis C virus (anti-HCV) negative patients with hepatocellular carcinoma. METHODS: A total of 550 patients, hospitalized with an initial diagnosis of HCC were retrospectively studied. Eighty-one of these patients were HBsAg-positive (HB group), 404 patients were anti-HCV positive (HC group). The other 65 patients were negative for both HBsAg and for anti-HCV (NBNC group). We purified HBV-X gene from HCC or non-tumorous liver tissue of 23 NBNC patients using PCR. RESULTS: Clinical features of NBNC as compared with HB and HC patients were as follows, respectively: non-cirrhosis rate (%): 57,37,15 (P = 0.02 for HB, P < 0.00001 for HC), the proportion of patients with normal ALT concentrations (%): 59,28,10 (P = 0.0002 for HB, P < 0.00001 for HC). Forty of 59 NBNC patients (68%) had anti-HBs and/or anti-HBc (healthy controls: 29%, P < 0.00001) and two of 56 had serum HBV DNA. Twelve of 23 NBNC patients had HBV-X gene in HCC and/or non-cancerous liver tissues (52%). None of 52 had serum HCV RNA. CONCLUSIONS: The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue. SN - 0106-9543 UR - https://www.unboundmedicine.com/medline/citation/12390472/Correlation_of_clinical_characteristics_with_detection_of_hepatitis_B_virus_X_gene_in_liver_tissue_in_HBsAg_negative_and_HCV_negative_hepatocellular_carcinoma_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0106-9543&amp;date=2002&amp;volume=22&amp;issue=5&amp;spage=374 DB - PRIME DP - Unbound Medicine ER -