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Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients.
Liver 2002; 22(5):374-9L

Abstract

PURPOSE

We studied the clinical features and the etiology of hepatitis B virus surface antigen (HBsAg)-negative and antibody to hepatitis C virus (anti-HCV) negative patients with hepatocellular carcinoma.

METHODS

A total of 550 patients, hospitalized with an initial diagnosis of HCC were retrospectively studied. Eighty-one of these patients were HBsAg-positive (HB group), 404 patients were anti-HCV positive (HC group). The other 65 patients were negative for both HBsAg and for anti-HCV (NBNC group). We purified HBV-X gene from HCC or non-tumorous liver tissue of 23 NBNC patients using PCR.

RESULTS

Clinical features of NBNC as compared with HB and HC patients were as follows, respectively: non-cirrhosis rate (%): 57,37,15 (P = 0.02 for HB, P < 0.00001 for HC), the proportion of patients with normal ALT concentrations (%): 59,28,10 (P = 0.0002 for HB, P < 0.00001 for HC). Forty of 59 NBNC patients (68%) had anti-HBs and/or anti-HBc (healthy controls: 29%, P < 0.00001) and two of 56 had serum HBV DNA. Twelve of 23 NBNC patients had HBV-X gene in HCC and/or non-cancerous liver tissues (52%). None of 52 had serum HCV RNA.

CONCLUSIONS

The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue.

Authors+Show Affiliations

Department of Gastroenterology, Saiseikai Kumamoto Hospital, Kumamoto City, 861-4193, Japan. h-yiochi@skh.saiseikai.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12390472

Citation

Higashi, Yoichiro, et al. "Correlation of Clinical Characteristics With Detection of Hepatitis B Virus X Gene in Liver Tissue in HBsAg-negative, and HCV-negative Hepatocellular Carcinoma Patients." Liver, vol. 22, no. 5, 2002, pp. 374-9.
Higashi Y, Tada S, Miyase S, et al. Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. Liver. 2002;22(5):374-9.
Higashi, Y., Tada, S., Miyase, S., Hirota, K., Imamura, H., Kamio, T., & Suko, H. (2002). Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. Liver, 22(5), pp. 374-9.
Higashi Y, et al. Correlation of Clinical Characteristics With Detection of Hepatitis B Virus X Gene in Liver Tissue in HBsAg-negative, and HCV-negative Hepatocellular Carcinoma Patients. Liver. 2002;22(5):374-9. PubMed PMID: 12390472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of clinical characteristics with detection of hepatitis B virus X gene in liver tissue in HBsAg-negative, and HCV-negative hepatocellular carcinoma patients. AU - Higashi,Yoichiro, AU - Tada,Shuji, AU - Miyase,Shuichi, AU - Hirota,Kazuhiko, AU - Imamura,Haruo, AU - Kamio,Takihiro, AU - Suko,Hironobu, PY - 2002/10/23/pubmed PY - 2003/4/16/medline PY - 2002/10/23/entrez SP - 374 EP - 9 JF - Liver JO - Liver VL - 22 IS - 5 N2 - PURPOSE: We studied the clinical features and the etiology of hepatitis B virus surface antigen (HBsAg)-negative and antibody to hepatitis C virus (anti-HCV) negative patients with hepatocellular carcinoma. METHODS: A total of 550 patients, hospitalized with an initial diagnosis of HCC were retrospectively studied. Eighty-one of these patients were HBsAg-positive (HB group), 404 patients were anti-HCV positive (HC group). The other 65 patients were negative for both HBsAg and for anti-HCV (NBNC group). We purified HBV-X gene from HCC or non-tumorous liver tissue of 23 NBNC patients using PCR. RESULTS: Clinical features of NBNC as compared with HB and HC patients were as follows, respectively: non-cirrhosis rate (%): 57,37,15 (P = 0.02 for HB, P < 0.00001 for HC), the proportion of patients with normal ALT concentrations (%): 59,28,10 (P = 0.0002 for HB, P < 0.00001 for HC). Forty of 59 NBNC patients (68%) had anti-HBs and/or anti-HBc (healthy controls: 29%, P < 0.00001) and two of 56 had serum HBV DNA. Twelve of 23 NBNC patients had HBV-X gene in HCC and/or non-cancerous liver tissues (52%). None of 52 had serum HCV RNA. CONCLUSIONS: The NBNC patients with HCC had a higher frequency of non-cirrhotic liver without liver injury. The presence of the HBV-X gene in HCC suggests a possible role of past HBV infection in the development of HCC. About half of NBNC HCC is associated with seronegativity for HBsAg and positivity for the HBV-X gene in liver tissue. SN - 0106-9543 UR - https://www.unboundmedicine.com/medline/citation/12390472/Correlation_of_clinical_characteristics_with_detection_of_hepatitis_B_virus_X_gene_in_liver_tissue_in_HBsAg_negative_and_HCV_negative_hepatocellular_carcinoma_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0106-9543&amp;date=2002&amp;volume=22&amp;issue=5&amp;spage=374 DB - PRIME DP - Unbound Medicine ER -