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Lifetime prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins.
Headache 2002; 42(8):754-65H

Abstract

OBJECTIVE

To examine the lifetime prevalence and other characteristics of recurrent primary headaches in twins.

BACKGROUND

The twin model may provide insights into the role of genetic and environmental influences in headache disorders. However, assumptions as to whether twins are representative of the general population, and whether monozygotic and dizygotic twins are similar have rarely been addressed.

METHODS

The study population consisted of a random sample of 17- to 82-year-old twins from the Swedish Twin Registry (n = 1329). Structured interviews on the telephone by lay personnel and the International Headache Society criteria were used for assessment and diagnosis of recurrent primary headaches. Prevalence data of the general population for migraine and tension-type headache was obtained from various published reports.

RESULTS

A total of 372 subjects (29%) had ever had recurrent headaches. In total, 241 recurrent headache sufferers fulfilled the criteria for migraine or tension-type headache, and the lifetime prevalence was 7.1% for migraine without aura, 1.4% for migraine always with aura, 1.9% for migraine occasionally with aura, 9.4% for episodic tension-type headache, and 1.3% for chronic tension-type headache. The lifetime prevalence of all migraine and all tension-type headache, including another 84 subjects fulfilling all but one of the criteria for migraine or tension-type headache, was 13.8% and 13.5%, respectively. The corresponding prevalence risk for women was 2.4 (95% confidence interval [CI] 1.7, 3.4) and 1.5 (95% CI 1.1, 2.1), respectively. Zygosity was not a significant predictor for migraine. In tension-type headache, the prevalence risk for dizygotic twins and unlike-sexed twins as compared with monozygotic twins was 1.9 (95% CI: 1.2, 3.1) and 1.8 (95% CI: 1.1, 2.9), respectively.

CONCLUSION

There is no twin-singleton or monozygotic-dizygotic difference for the risk of migraine. In tension-type headache, twins seem to have a lower risk than singletons, and this is especially true for monozygotic twins.

Authors+Show Affiliations

Division of Neurology, Neurotec, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

12390638

Citation

Svensson, Dan A., et al. "Lifetime Prevalence and Characteristics of Recurrent Primary Headaches in a Population-based Sample of Swedish Twins." Headache, vol. 42, no. 8, 2002, pp. 754-65.
Svensson DA, Ekbom K, Larsson B, et al. Lifetime prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins. Headache. 2002;42(8):754-65.
Svensson, D. A., Ekbom, K., Larsson, B., & Waldenlind, E. (2002). Lifetime prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins. Headache, 42(8), pp. 754-65.
Svensson DA, et al. Lifetime Prevalence and Characteristics of Recurrent Primary Headaches in a Population-based Sample of Swedish Twins. Headache. 2002;42(8):754-65. PubMed PMID: 12390638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifetime prevalence and characteristics of recurrent primary headaches in a population-based sample of Swedish twins. AU - Svensson,Dan A, AU - Ekbom,Karl, AU - Larsson,Bo, AU - Waldenlind,Elisabet, PY - 2002/10/23/pubmed PY - 2002/12/3/medline PY - 2002/10/23/entrez SP - 754 EP - 65 JF - Headache JO - Headache VL - 42 IS - 8 N2 - OBJECTIVE: To examine the lifetime prevalence and other characteristics of recurrent primary headaches in twins. BACKGROUND: The twin model may provide insights into the role of genetic and environmental influences in headache disorders. However, assumptions as to whether twins are representative of the general population, and whether monozygotic and dizygotic twins are similar have rarely been addressed. METHODS: The study population consisted of a random sample of 17- to 82-year-old twins from the Swedish Twin Registry (n = 1329). Structured interviews on the telephone by lay personnel and the International Headache Society criteria were used for assessment and diagnosis of recurrent primary headaches. Prevalence data of the general population for migraine and tension-type headache was obtained from various published reports. RESULTS: A total of 372 subjects (29%) had ever had recurrent headaches. In total, 241 recurrent headache sufferers fulfilled the criteria for migraine or tension-type headache, and the lifetime prevalence was 7.1% for migraine without aura, 1.4% for migraine always with aura, 1.9% for migraine occasionally with aura, 9.4% for episodic tension-type headache, and 1.3% for chronic tension-type headache. The lifetime prevalence of all migraine and all tension-type headache, including another 84 subjects fulfilling all but one of the criteria for migraine or tension-type headache, was 13.8% and 13.5%, respectively. The corresponding prevalence risk for women was 2.4 (95% confidence interval [CI] 1.7, 3.4) and 1.5 (95% CI 1.1, 2.1), respectively. Zygosity was not a significant predictor for migraine. In tension-type headache, the prevalence risk for dizygotic twins and unlike-sexed twins as compared with monozygotic twins was 1.9 (95% CI: 1.2, 3.1) and 1.8 (95% CI: 1.1, 2.9), respectively. CONCLUSION: There is no twin-singleton or monozygotic-dizygotic difference for the risk of migraine. In tension-type headache, twins seem to have a lower risk than singletons, and this is especially true for monozygotic twins. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/12390638/Lifetime_prevalence_and_characteristics_of_recurrent_primary_headaches_in_a_population_based_sample_of_Swedish_twins_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0017-8748&date=2002&volume=42&issue=8&spage=754 DB - PRIME DP - Unbound Medicine ER -