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[Pathophysiology of migraine: models to explain the generation of migraine headache].
Anaesthesist. 2002 Aug; 51(8):661-7.A

Abstract

Migraine attacks can be elicited by many different trigger situations such as light, food and the menstruation cycle. However, patients share a common pathophysiology, and a number of theories have been proposed as to how migraine can be generated. After a brief introduction of the trigeminal nociceptive system, 4 attempts to explain the generation of migraine attacks are described and discussed: One deals with the "cortical spreading depression (CSD) theory" which favors a cortical dysfunction. The second provides some evidence that a genetic mutation of calcium channels might be the cause. The third is based on a pathophysiological role of endogenous serotonin because serotonin agonists are effective drugs in the treatment of migraine and the last one postulates a migraine generator in the brainstem.

Authors+Show Affiliations

Institut für Physiologie, Abteilung Neurophysiologie, Friedrich-Schiller-Universität Jena, Germany. aebe@mti-n.uni-jena.de

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

12391526

Citation

Ebersberger, A. "[Pathophysiology of Migraine: Models to Explain the Generation of Migraine Headache]." Der Anaesthesist, vol. 51, no. 8, 2002, pp. 661-7.
Ebersberger A. [Pathophysiology of migraine: models to explain the generation of migraine headache]. Anaesthesist. 2002;51(8):661-7.
Ebersberger, A. (2002). [Pathophysiology of migraine: models to explain the generation of migraine headache]. Der Anaesthesist, 51(8), 661-7.
Ebersberger A. [Pathophysiology of Migraine: Models to Explain the Generation of Migraine Headache]. Anaesthesist. 2002;51(8):661-7. PubMed PMID: 12391526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pathophysiology of migraine: models to explain the generation of migraine headache]. A1 - Ebersberger,A, PY - 2002/10/23/pubmed PY - 2002/12/11/medline PY - 2002/10/23/entrez SP - 661 EP - 7 JF - Der Anaesthesist JO - Anaesthesist VL - 51 IS - 8 N2 - Migraine attacks can be elicited by many different trigger situations such as light, food and the menstruation cycle. However, patients share a common pathophysiology, and a number of theories have been proposed as to how migraine can be generated. After a brief introduction of the trigeminal nociceptive system, 4 attempts to explain the generation of migraine attacks are described and discussed: One deals with the "cortical spreading depression (CSD) theory" which favors a cortical dysfunction. The second provides some evidence that a genetic mutation of calcium channels might be the cause. The third is based on a pathophysiological role of endogenous serotonin because serotonin agonists are effective drugs in the treatment of migraine and the last one postulates a migraine generator in the brainstem. SN - 0003-2417 UR - https://www.unboundmedicine.com/medline/citation/12391526/[Pathophysiology_of_migraine:_models_to_explain_the_generation_of_migraine_headache]_ L2 - https://dx.doi.org/10.1007/s00101-002-0342-5 DB - PRIME DP - Unbound Medicine ER -