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Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba.
Planta Med. 2002 Oct; 68(10):932-4.PM

Abstract

Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.

Authors+Show Affiliations

Oh H
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea.
Ko EK
No affiliation info available
Jun JY
No affiliation info available
Oh MH
No affiliation info available
Park SU
No affiliation info available
Kang KH
No affiliation info available
Lee HS
No affiliation info available
Kim YC
No affiliation info available

MeSH

Biphenyl CompoundsCell LineChemical and Drug Induced Liver InjuryCoumarinsFlavonoidsFree Radical ScavengersHumansInhibitory Concentration 50MorusPhytotherapyPicratesPlant ExtractsPlant StructuresStilbenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12391560

Citation

Oh, Hyuncheol, et al. "Hepatoprotective and Free Radical Scavenging Activities of Prenylflavonoids, Coumarin, and Stilbene From Morus Alba." Planta Medica, vol. 68, no. 10, 2002, pp. 932-4.
Oh H, Ko EK, Jun JY, et al. Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Planta Med. 2002;68(10):932-4.
Oh, H., Ko, E. K., Jun, J. Y., Oh, M. H., Park, S. U., Kang, K. H., Lee, H. S., & Kim, Y. C. (2002). Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. Planta Medica, 68(10), 932-4.
Oh H, et al. Hepatoprotective and Free Radical Scavenging Activities of Prenylflavonoids, Coumarin, and Stilbene From Morus Alba. Planta Med. 2002;68(10):932-4. PubMed PMID: 12391560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective and free radical scavenging activities of prenylflavonoids, coumarin, and stilbene from Morus alba. AU - Oh,Hyuncheol, AU - Ko,Eun-Kyung, AU - Jun,Jung-Yang, AU - Oh,Myung-Hoon, AU - Park,Sung-Uk, AU - Kang,Ki-Hong, AU - Lee,Ho-Sub, AU - Kim,Youn-Chul, PY - 2002/10/23/pubmed PY - 2002/12/18/medline PY - 2002/10/23/entrez SP - 932 EP - 4 JF - Planta medica JO - Planta Med VL - 68 IS - 10 N2 - Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with the IC(50) values of 19.1 +/- 3.6 and 3.81 +/- 0.5 microM, respectively. Compound 4 exhibited a DPPH free radical scavenging effect (IC(50) = 23.4 +/- 1.5 microM). Compounds 2 and 4 showed hepatoprotective effects with EC(50) values of 10.3 +/- 0.42 and 32.3 +/- 2.62 micro, respectively, on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12391560/Hepatoprotective_and_free_radical_scavenging_activities_of_prenylflavonoids_coumarin_and_stilbene_from_Morus_alba_ DB - PRIME DP - Unbound Medicine ER -