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Turnover of synaptic membranes: age-related changes and modulation by dietary restriction.
J Neurosci Res. 2002 Nov 01; 70(3):290-7.JN

Abstract

We examined age-related changes in the turnover rates of synaptic membrane components that might underlie the decrease in synaptic functions in senescence. Synaptic membrane constituents were labeled in vivo with deuterium and the disappearance of the deuterated molecules from synaptic membranes was measured by mass spectrometry. The turnover rates of phosphatidylcholine, phosphatidylethanolamine, cholesterol, and synaptophysin were all shown to slow down with aging. Dietary restriction, which is known to retard various aging processes, was found to decrease the turnover rates of membrane lipid species. Consequently, the fatty acid composition in phospholipids remained unchanged in the synaptic plasma membranes of food restricted mice. In contrast, the turnover rate of synaptophysin was accelerated under dietary restriction. This may mean that increased turnover enhances the removal of damaged proteins from membranes.

Authors+Show Affiliations

Neuronal Function Research Group, Division of Neuroscience, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan. andos@tmig.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12391588

Citation

Ando, Susumu, et al. "Turnover of Synaptic Membranes: Age-related Changes and Modulation By Dietary Restriction." Journal of Neuroscience Research, vol. 70, no. 3, 2002, pp. 290-7.
Ando S, Tanaka Y, Toyoda nee Ono Y, et al. Turnover of synaptic membranes: age-related changes and modulation by dietary restriction. J Neurosci Res. 2002;70(3):290-7.
Ando, S., Tanaka, Y., Toyoda nee Ono, Y., Kon, K., & Kawashima, S. (2002). Turnover of synaptic membranes: age-related changes and modulation by dietary restriction. Journal of Neuroscience Research, 70(3), 290-7.
Ando S, et al. Turnover of Synaptic Membranes: Age-related Changes and Modulation By Dietary Restriction. J Neurosci Res. 2002 Nov 1;70(3):290-7. PubMed PMID: 12391588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Turnover of synaptic membranes: age-related changes and modulation by dietary restriction. AU - Ando,Susumu, AU - Tanaka,Yasukazu, AU - Toyoda nee Ono,Yuriko, AU - Kon,Kazuo, AU - Kawashima,Sei-Ichi, PY - 2002/10/23/pubmed PY - 2002/12/17/medline PY - 2002/10/23/entrez SP - 290 EP - 7 JF - Journal of neuroscience research JO - J Neurosci Res VL - 70 IS - 3 N2 - We examined age-related changes in the turnover rates of synaptic membrane components that might underlie the decrease in synaptic functions in senescence. Synaptic membrane constituents were labeled in vivo with deuterium and the disappearance of the deuterated molecules from synaptic membranes was measured by mass spectrometry. The turnover rates of phosphatidylcholine, phosphatidylethanolamine, cholesterol, and synaptophysin were all shown to slow down with aging. Dietary restriction, which is known to retard various aging processes, was found to decrease the turnover rates of membrane lipid species. Consequently, the fatty acid composition in phospholipids remained unchanged in the synaptic plasma membranes of food restricted mice. In contrast, the turnover rate of synaptophysin was accelerated under dietary restriction. This may mean that increased turnover enhances the removal of damaged proteins from membranes. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/12391588/Turnover_of_synaptic_membranes:_age_related_changes_and_modulation_by_dietary_restriction_ L2 - https://doi.org/10.1002/jnr.10352 DB - PRIME DP - Unbound Medicine ER -