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The role of particle properties in pharmaceutical powder inhalation formulations.
J Aerosol Med. 2002 Fall; 15(3):325-30.JA

Abstract

Pharmaceutical aerosol delivery is undergoing dramatic changes in both inhaler device and formulation aspects. There is a rapid move from the traditional propellant-driven metered dose inhalers to the high performance liquid atomizers and dry powder inhalers (DPIs). DPIs involving the dispersion of powders into aerosols by an inhaler device are particularly attractive as dry powders generally have greater chemical stability than liquids used in atomizers. Delivery of therapeutic proteins as dry powder aerosols is of high commerical interest. However, production and formulation of dry powders for inhalation can be difficult and challenging due to the potential physical instability of the powder. Dry powders consisting of micro- or nano-sized particles are inherently adhesive and cohesive, leading to highly variable dose accuracy and poor aerosol performance. Particle engineering via the use of appropriate pharmaceutical excipients and processing parameters can produce particles of optimal morphologies and surface properties which would enhance aerosol generation. Some of the key determinants for successful dispersion of pharmaceutical powders suitable for inhalation are reviewed with an emphasis on the practical significance.

Authors+Show Affiliations

Faculty of Pharmacy, University of Sydney, Sydney, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12396421

Citation

Chew, Nora Y K., and Hak-Kim Chan. "The Role of Particle Properties in Pharmaceutical Powder Inhalation Formulations." Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine, vol. 15, no. 3, 2002, pp. 325-30.
Chew NY, Chan HK. The role of particle properties in pharmaceutical powder inhalation formulations. J Aerosol Med. 2002;15(3):325-30.
Chew, N. Y., & Chan, H. K. (2002). The role of particle properties in pharmaceutical powder inhalation formulations. Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine, 15(3), 325-30.
Chew NY, Chan HK. The Role of Particle Properties in Pharmaceutical Powder Inhalation Formulations. J Aerosol Med. 2002;15(3):325-30. PubMed PMID: 12396421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of particle properties in pharmaceutical powder inhalation formulations. AU - Chew,Nora Y K, AU - Chan,Hak-Kim, PY - 2002/10/25/pubmed PY - 2002/11/26/medline PY - 2002/10/25/entrez SP - 325 EP - 30 JF - Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine JO - J Aerosol Med VL - 15 IS - 3 N2 - Pharmaceutical aerosol delivery is undergoing dramatic changes in both inhaler device and formulation aspects. There is a rapid move from the traditional propellant-driven metered dose inhalers to the high performance liquid atomizers and dry powder inhalers (DPIs). DPIs involving the dispersion of powders into aerosols by an inhaler device are particularly attractive as dry powders generally have greater chemical stability than liquids used in atomizers. Delivery of therapeutic proteins as dry powder aerosols is of high commerical interest. However, production and formulation of dry powders for inhalation can be difficult and challenging due to the potential physical instability of the powder. Dry powders consisting of micro- or nano-sized particles are inherently adhesive and cohesive, leading to highly variable dose accuracy and poor aerosol performance. Particle engineering via the use of appropriate pharmaceutical excipients and processing parameters can produce particles of optimal morphologies and surface properties which would enhance aerosol generation. Some of the key determinants for successful dispersion of pharmaceutical powders suitable for inhalation are reviewed with an emphasis on the practical significance. SN - 0894-2684 UR - https://www.unboundmedicine.com/medline/citation/12396421/The_role_of_particle_properties_in_pharmaceutical_powder_inhalation_formulations_ L2 - https://www.liebertpub.com/doi/full/10.1089/089426802760292672?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -