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Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study.
Allergol Immunopathol (Madr) 2002 Sep-Oct; 30(5):255-8AI

Abstract

Helicobacter pylori has been involved in the pathogenesis of chronic idiopathic urticaria (CIU) in patients suffering both CIU and H. pylori infection. We selected 49 patients with 13C urea breath test positive, long-lasting CIU and H. pylori infection; 20 remained symptomatic, had positive urease test or H. pylori histologic identification in gastric biopsy material and accepted to participate in a pacebo-controlled treatment trial. They were randomized for a 7-day, double-blind, placebo-controlled H. pylori eradication treatment with amoxicillin, clarithromycin and omeprazol or placebo. H. pylori eradication was assessed by a second 13C urea breath test six weeks after the end of treatment. We observed a significant improvement of more than 70 % of CIU; baseline clinical score was seen in 4 of the 9 (44 %) patients who eradicated H. pylori after active treatment and in 1 of the 7 (12,3 %) of those who did not (p = 0.19). No clinical differences in CIU characteristics were found between patients with and without improvement. No serious adverse effects were observed in either treatment group. We conclude that the eradication of H. pylori may be useful for patients suffering long-lasting CIU and H. pylori infection, although theses results did not reach statistical significance probably owing to the strict conditions of the recruitment.

Authors+Show Affiliations

Allergy Unit. Hospital Universitari Joan XXIII. Institut d'Estudis Avançats. Universitat Rovira i Virgili. Tarragona. Spain. pgaigj@hjxxiii.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12396958

Citation

Gaig, P, et al. "Efficacy of the Eradication of Helicobacter Pylori Infection in Patients With Chronic Urticaria. a Placebo-controlled Double Blind Study." Allergologia Et Immunopathologia, vol. 30, no. 5, 2002, pp. 255-8.
Gaig P, García-Ortega P, Enrique E, et al. Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. Allergol Immunopathol (Madr). 2002;30(5):255-8.
Gaig, P., García-Ortega, P., Enrique, E., Papo, M., Quer, J. C., & Richard, C. (2002). Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. Allergologia Et Immunopathologia, 30(5), pp. 255-8.
Gaig P, et al. Efficacy of the Eradication of Helicobacter Pylori Infection in Patients With Chronic Urticaria. a Placebo-controlled Double Blind Study. Allergol Immunopathol (Madr). 2002;30(5):255-8. PubMed PMID: 12396958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. AU - Gaig,P, AU - García-Ortega,P, AU - Enrique,E, AU - Papo,M, AU - Quer,J C, AU - Richard,C, PY - 2002/10/25/pubmed PY - 2003/1/31/medline PY - 2002/10/25/entrez SP - 255 EP - 8 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 30 IS - 5 N2 - Helicobacter pylori has been involved in the pathogenesis of chronic idiopathic urticaria (CIU) in patients suffering both CIU and H. pylori infection. We selected 49 patients with 13C urea breath test positive, long-lasting CIU and H. pylori infection; 20 remained symptomatic, had positive urease test or H. pylori histologic identification in gastric biopsy material and accepted to participate in a pacebo-controlled treatment trial. They were randomized for a 7-day, double-blind, placebo-controlled H. pylori eradication treatment with amoxicillin, clarithromycin and omeprazol or placebo. H. pylori eradication was assessed by a second 13C urea breath test six weeks after the end of treatment. We observed a significant improvement of more than 70 % of CIU; baseline clinical score was seen in 4 of the 9 (44 %) patients who eradicated H. pylori after active treatment and in 1 of the 7 (12,3 %) of those who did not (p = 0.19). No clinical differences in CIU characteristics were found between patients with and without improvement. No serious adverse effects were observed in either treatment group. We conclude that the eradication of H. pylori may be useful for patients suffering long-lasting CIU and H. pylori infection, although theses results did not reach statistical significance probably owing to the strict conditions of the recruitment. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/12396958/Efficacy_of_the_eradication_of_Helicobacter_pylori_infection_in_patients_with_chronic_urticaria__A_placebo_controlled_double_blind_study_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0301-0546/30/255 DB - PRIME DP - Unbound Medicine ER -