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Neopterin production, tryptophan degradation, and mental depression--what is the link?
Brain Behav Immun 2002; 16(5):590-5BB

Abstract

The cytokine interferon-gamma stimulates human monocytes/macrophages to release large amounts of neopterin. Increased neopterin concentrations in body fluids of patients are observed during diseases with activated cellular (=TH1-type) immune response such as allograft rejection, virus infections, autoimmune disorders, or malignant tumors but also in neurodegenerative diseases or during pregnancy. In various cells interferon-gamma induces indoleamine 2,3-dioxygenase (IDO) which degrades tryptophan via the kynurenine pathway. Therefore like increased neopterin formation, enhanced tryptophan degradation is observed in diseases concomitant with cellular immune activation. Disturbed metabolism of tryptophan affects biosynthesis of neurotransmitter 5-hydroxytryptamine (serotonin), and it appears to be associated with an increased susceptibility for depression. In fact, enhanced neopterin concentrations together with increased degradation of tryptophan and low serum levels of tryptophan correlate with neuropsychiatric abnormalities like cognitive decline and depressive symptoms especially in long-lasting and chronic diseases. Activation of IDO could represent an important link between the immunological network and the pathogenesis of depression.

Authors+Show Affiliations

Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, Innsbruck A-6020, Austria.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12401473

Citation

Widner, Bernhard, et al. "Neopterin Production, Tryptophan Degradation, and Mental Depression--what Is the Link?" Brain, Behavior, and Immunity, vol. 16, no. 5, 2002, pp. 590-5.
Widner B, Laich A, Sperner-Unterweger B, et al. Neopterin production, tryptophan degradation, and mental depression--what is the link? Brain Behav Immun. 2002;16(5):590-5.
Widner, B., Laich, A., Sperner-Unterweger, B., Ledochowski, M., & Fuchs, D. (2002). Neopterin production, tryptophan degradation, and mental depression--what is the link? Brain, Behavior, and Immunity, 16(5), pp. 590-5.
Widner B, et al. Neopterin Production, Tryptophan Degradation, and Mental Depression--what Is the Link. Brain Behav Immun. 2002;16(5):590-5. PubMed PMID: 12401473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neopterin production, tryptophan degradation, and mental depression--what is the link? AU - Widner,Bernhard, AU - Laich,Andreas, AU - Sperner-Unterweger,Barbara, AU - Ledochowski,Maximilian, AU - Fuchs,Dietmar, PY - 2002/10/29/pubmed PY - 2003/5/29/medline PY - 2002/10/29/entrez SP - 590 EP - 5 JF - Brain, behavior, and immunity JO - Brain Behav. Immun. VL - 16 IS - 5 N2 - The cytokine interferon-gamma stimulates human monocytes/macrophages to release large amounts of neopterin. Increased neopterin concentrations in body fluids of patients are observed during diseases with activated cellular (=TH1-type) immune response such as allograft rejection, virus infections, autoimmune disorders, or malignant tumors but also in neurodegenerative diseases or during pregnancy. In various cells interferon-gamma induces indoleamine 2,3-dioxygenase (IDO) which degrades tryptophan via the kynurenine pathway. Therefore like increased neopterin formation, enhanced tryptophan degradation is observed in diseases concomitant with cellular immune activation. Disturbed metabolism of tryptophan affects biosynthesis of neurotransmitter 5-hydroxytryptamine (serotonin), and it appears to be associated with an increased susceptibility for depression. In fact, enhanced neopterin concentrations together with increased degradation of tryptophan and low serum levels of tryptophan correlate with neuropsychiatric abnormalities like cognitive decline and depressive symptoms especially in long-lasting and chronic diseases. Activation of IDO could represent an important link between the immunological network and the pathogenesis of depression. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/12401473/Neopterin_production_tryptophan_degradation_and_mental_depression__what_is_the_link L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889159102000065 DB - PRIME DP - Unbound Medicine ER -