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Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.
Nat Neurosci. 2002 Dec; 5(12):1319-26.NN

Abstract

The increase in pain sensitivity that follows injury is regulated by superficially located projection neurons in the dorsal horn of the spinal cord that express the neurokinin-1 (NK1) receptor. After selective ablation of these neurons in rats, we identified changes in receptive field size, mechanical and thermal coding and central sensitization of deeper dorsal horn neurons that are important for both pain sensations and reflexes. We were able to reproduce these changes by pharmacological block of descending serotonergic facilitatory pathways. Using Fos histochemistry, we found changes in the activation of serotonergic neurons in the brainstem as well as evidence for a loss of descending control of spinal excitability. We conclude that NK1-positive spinal projection neurons, activated by primary afferent input, project to higher brain areas that control spinal excitability--and therefore pain sensitivity--primarily through descending pathways from the brainstem.

Authors+Show Affiliations

Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK. ucklrsu@ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12402039

Citation

Suzuki, Rie, et al. "Superficial NK1-expressing Neurons Control Spinal Excitability Through Activation of Descending Pathways." Nature Neuroscience, vol. 5, no. 12, 2002, pp. 1319-26.
Suzuki R, Morcuende S, Webber M, et al. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci. 2002;5(12):1319-26.
Suzuki, R., Morcuende, S., Webber, M., Hunt, S. P., & Dickenson, A. H. (2002). Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nature Neuroscience, 5(12), 1319-26.
Suzuki R, et al. Superficial NK1-expressing Neurons Control Spinal Excitability Through Activation of Descending Pathways. Nat Neurosci. 2002;5(12):1319-26. PubMed PMID: 12402039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. AU - Suzuki,Rie, AU - Morcuende,Sara, AU - Webber,Mark, AU - Hunt,Stephen P, AU - Dickenson,Anthony H, PY - 2002/08/07/received PY - 2002/09/04/accepted PY - 2002/10/29/pubmed PY - 2003/1/7/medline PY - 2002/10/29/entrez SP - 1319 EP - 26 JF - Nature neuroscience JO - Nat. Neurosci. VL - 5 IS - 12 N2 - The increase in pain sensitivity that follows injury is regulated by superficially located projection neurons in the dorsal horn of the spinal cord that express the neurokinin-1 (NK1) receptor. After selective ablation of these neurons in rats, we identified changes in receptive field size, mechanical and thermal coding and central sensitization of deeper dorsal horn neurons that are important for both pain sensations and reflexes. We were able to reproduce these changes by pharmacological block of descending serotonergic facilitatory pathways. Using Fos histochemistry, we found changes in the activation of serotonergic neurons in the brainstem as well as evidence for a loss of descending control of spinal excitability. We conclude that NK1-positive spinal projection neurons, activated by primary afferent input, project to higher brain areas that control spinal excitability--and therefore pain sensitivity--primarily through descending pathways from the brainstem. SN - 1097-6256 UR - https://www.unboundmedicine.com/medline/citation/12402039/Superficial_NK1_expressing_neurons_control_spinal_excitability_through_activation_of_descending_pathways_ L2 - http://dx.doi.org/10.1038/nn966 DB - PRIME DP - Unbound Medicine ER -