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Osteosarcoma after bone marrow transplantation for acute lymphoblastic leukemia.
Int J Clin Oncol. 2002 Oct; 7(5):318-21.IJ

Abstract

A male patient initially diagnosed with acute lymphoblastic leukemia at age 9 years received chemotherapy (total body irradiation, 12 Gy) followed by allogeneic bone marrow transplantation. Since then, he had been in complete remission. Three years after the bone marrow transplantation, he complained of increasing pain in the right knee. Radiological and histological examinations led to a diagnosis of conventional osteosarcoma. We performed intensive chemotherapy and wide local excision of the osteosarcoma. Intensive chemotherapy was accomplished as planned, although recovery from myelosuppression was delayed during some cycles. Polymerase chain reaction-single-strand conformation polymorphism analysis revealed a p53 gene mutation in exon 7 in the tumor cells, but not in skin or blood cells. This is an extremely rare case of osteosarcoma after bone marrow transplantation.

Authors+Show Affiliations

Department of Orthopaedics, Osaka University Graduate School of Medicine, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12402067

Citation

Asai, Tatsuya, et al. "Osteosarcoma After Bone Marrow Transplantation for Acute Lymphoblastic Leukemia." International Journal of Clinical Oncology, vol. 7, no. 5, 2002, pp. 318-21.
Asai T, Myoui A, Fujimoto T, et al. Osteosarcoma after bone marrow transplantation for acute lymphoblastic leukemia. Int J Clin Oncol. 2002;7(5):318-21.
Asai, T., Myoui, A., Fujimoto, T., Hara, J., Aozasa, K., & Yoshikawa, H. (2002). Osteosarcoma after bone marrow transplantation for acute lymphoblastic leukemia. International Journal of Clinical Oncology, 7(5), 318-21.
Asai T, et al. Osteosarcoma After Bone Marrow Transplantation for Acute Lymphoblastic Leukemia. Int J Clin Oncol. 2002;7(5):318-21. PubMed PMID: 12402067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteosarcoma after bone marrow transplantation for acute lymphoblastic leukemia. AU - Asai,Tatsuya, AU - Myoui,Akira, AU - Fujimoto,Tetsuho, AU - Hara,Junichi, AU - Aozasa,Katsuyuki, AU - Yoshikawa,Hideki, PY - 2002/10/29/pubmed PY - 2003/2/14/medline PY - 2002/10/29/entrez SP - 318 EP - 21 JF - International journal of clinical oncology JO - Int J Clin Oncol VL - 7 IS - 5 N2 - A male patient initially diagnosed with acute lymphoblastic leukemia at age 9 years received chemotherapy (total body irradiation, 12 Gy) followed by allogeneic bone marrow transplantation. Since then, he had been in complete remission. Three years after the bone marrow transplantation, he complained of increasing pain in the right knee. Radiological and histological examinations led to a diagnosis of conventional osteosarcoma. We performed intensive chemotherapy and wide local excision of the osteosarcoma. Intensive chemotherapy was accomplished as planned, although recovery from myelosuppression was delayed during some cycles. Polymerase chain reaction-single-strand conformation polymorphism analysis revealed a p53 gene mutation in exon 7 in the tumor cells, but not in skin or blood cells. This is an extremely rare case of osteosarcoma after bone marrow transplantation. SN - 1341-9625 UR - https://www.unboundmedicine.com/medline/citation/12402067/Osteosarcoma_after_bone_marrow_transplantation_for_acute_lymphoblastic_leukemia_ L2 - http://dx.doi.org/10.1007/s101470200047 DB - PRIME DP - Unbound Medicine ER -