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The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety.
Eur J Neurosci. 2002 Oct; 16(7):1395-8.EJ

Abstract

The aim of this study was to compare the effects of the genetic and pharmacological disruption of CB1 cannabinoid receptors on the elevated plus-maze test of anxiety. In the first experiment, the behaviour of CB1-knockout mice and wild-type mice was compared. In the second experiment, the cannabinoid antagonist SR141716A (0, 1, and 3 mg/kg) was administered to both CB1-knockout and wild type mice. Untreated CB1-knockout mice showed a reduced exploration of the open arms of the plus-maze apparatus, thus appearing more anxious than the wild-type animals, however no changes in locomotion were noticed. The vehicle-injected CB1-knockout mice from the second experiment also showed increased anxiety as compared with wild types. Surprisingly, the cannabinoid antagonist SR141716A reduced anxiety in both wild type and CB1 knockout mice. Locomotor behaviour was only marginally affected. Recent evidence suggests the existence of a novel cannabinoid receptor in the brain. It has also been shown that SR141716A binds to both the CB1 and the putative novel receptor. The data presented here supports these findings, as the cannabinoid receptor antagonist affected anxiety in both wild type and CB1-knockout mice. Tentatively, it may be suggested that the discrepancy between the effects of the genetic and pharmacological blockade of the CB1 receptor suggests that the novel receptor plays a role in anxiety.

Authors+Show Affiliations

Institute of Experimental Medicine, Hungarian Academy of Science, 1450 Budapest, Hungary. haller@koki.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12405999

Citation

Haller, J, et al. "The Effects of Genetic and Pharmacological Blockade of the CB1 Cannabinoid Receptor On Anxiety." The European Journal of Neuroscience, vol. 16, no. 7, 2002, pp. 1395-8.
Haller J, Bakos N, Szirmay M, et al. The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. Eur J Neurosci. 2002;16(7):1395-8.
Haller, J., Bakos, N., Szirmay, M., Ledent, C., & Freund, T. F. (2002). The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. The European Journal of Neuroscience, 16(7), 1395-8.
Haller J, et al. The Effects of Genetic and Pharmacological Blockade of the CB1 Cannabinoid Receptor On Anxiety. Eur J Neurosci. 2002;16(7):1395-8. PubMed PMID: 12405999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety. AU - Haller,J, AU - Bakos,N, AU - Szirmay,M, AU - Ledent,C, AU - Freund,T F, PY - 2002/10/31/pubmed PY - 2002/12/31/medline PY - 2002/10/31/entrez SP - 1395 EP - 8 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 16 IS - 7 N2 - The aim of this study was to compare the effects of the genetic and pharmacological disruption of CB1 cannabinoid receptors on the elevated plus-maze test of anxiety. In the first experiment, the behaviour of CB1-knockout mice and wild-type mice was compared. In the second experiment, the cannabinoid antagonist SR141716A (0, 1, and 3 mg/kg) was administered to both CB1-knockout and wild type mice. Untreated CB1-knockout mice showed a reduced exploration of the open arms of the plus-maze apparatus, thus appearing more anxious than the wild-type animals, however no changes in locomotion were noticed. The vehicle-injected CB1-knockout mice from the second experiment also showed increased anxiety as compared with wild types. Surprisingly, the cannabinoid antagonist SR141716A reduced anxiety in both wild type and CB1 knockout mice. Locomotor behaviour was only marginally affected. Recent evidence suggests the existence of a novel cannabinoid receptor in the brain. It has also been shown that SR141716A binds to both the CB1 and the putative novel receptor. The data presented here supports these findings, as the cannabinoid receptor antagonist affected anxiety in both wild type and CB1-knockout mice. Tentatively, it may be suggested that the discrepancy between the effects of the genetic and pharmacological blockade of the CB1 receptor suggests that the novel receptor plays a role in anxiety. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/12405999/The_effects_of_genetic_and_pharmacological_blockade_of_the_CB1_cannabinoid_receptor_on_anxiety_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2002&volume=16&issue=7&spage=1395 DB - PRIME DP - Unbound Medicine ER -