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Increased leukotrienes in exhaled breath condensate in childhood asthma.
Am J Respir Crit Care Med. 2002 Nov 15; 166(10):1345-9.AJ

Abstract

Cysteinyl leukotrienes (cys-LTs; LTC4, LTD4, and LTE4) are generated predominantly by mast cells and eosinophils and induce airway smooth muscle contraction, microvascular leakage, and mucous hypersecretion whereas leukotriene B4 (LTB4) is a potent chemoattractant of neutrophils. We measured cys-LTs and LTB4 in exhaled breath condensate from children aged 7-14 years including healthy nonatopic children (n = 11) and children with mild intermittent asthma (steroid naive, n = 11), mild persistent asthma (low-dose inhaled steroid treatment, n = 13), or moderate to severe persistent asthma (high-dose inhaled steroid treatment, n = 13). Exhaled LTB4 levels were increased in patients with mild and moderate to severe persistent asthma compared with patients with mild intermittent asthma (126.0 +/- 8.8 and 131.9 +/- 7.1 versus 52.7 +/- 3.8 pg/ml, p < 0.001 and p < 0.0001) and normal subjects (126.0 +/- 8.8 and 131.9 +/- 7.1 versus 47.9 +/- 4.1 pg/ml, p < 0.0001). Elevated exhaled cys-LT levels were found in patients with mild and moderate to severe persistent asthma compared with normal subjects (27.9 +/- 2.8 and 31.5 +/- 4.5 versus 18.5 +/- 0.5 pg/ml, p < 0.01 and p < 0.05). There was an inverse correlation between exhaled cys-LTs and LTB4 in patients with mild persistent asthma. We conclude that exhaled cys-LTs and LTB4 may be noninvasive markers of airway inflammation in pediatric asthma.

Authors+Show Affiliations

Department of Thoracic Medicine and Department of Pediatric Respiratory Care, Imperial College School of Medicine, National Heart and Lung Institute, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12406853

Citation

Csoma, Zsuzsanna, et al. "Increased Leukotrienes in Exhaled Breath Condensate in Childhood Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 10, 2002, pp. 1345-9.
Csoma Z, Kharitonov SA, Balint B, et al. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med. 2002;166(10):1345-9.
Csoma, Z., Kharitonov, S. A., Balint, B., Bush, A., Wilson, N. M., & Barnes, P. J. (2002). Increased leukotrienes in exhaled breath condensate in childhood asthma. American Journal of Respiratory and Critical Care Medicine, 166(10), 1345-9.
Csoma Z, et al. Increased Leukotrienes in Exhaled Breath Condensate in Childhood Asthma. Am J Respir Crit Care Med. 2002 Nov 15;166(10):1345-9. PubMed PMID: 12406853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased leukotrienes in exhaled breath condensate in childhood asthma. AU - Csoma,Zsuzsanna, AU - Kharitonov,Sergei A, AU - Balint,Beatrix, AU - Bush,Andrew, AU - Wilson,Nicola M, AU - Barnes,Peter J, Y1 - 2002/09/05/ PY - 2002/10/31/pubmed PY - 2003/1/9/medline PY - 2002/10/31/entrez SP - 1345 EP - 9 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 166 IS - 10 N2 - Cysteinyl leukotrienes (cys-LTs; LTC4, LTD4, and LTE4) are generated predominantly by mast cells and eosinophils and induce airway smooth muscle contraction, microvascular leakage, and mucous hypersecretion whereas leukotriene B4 (LTB4) is a potent chemoattractant of neutrophils. We measured cys-LTs and LTB4 in exhaled breath condensate from children aged 7-14 years including healthy nonatopic children (n = 11) and children with mild intermittent asthma (steroid naive, n = 11), mild persistent asthma (low-dose inhaled steroid treatment, n = 13), or moderate to severe persistent asthma (high-dose inhaled steroid treatment, n = 13). Exhaled LTB4 levels were increased in patients with mild and moderate to severe persistent asthma compared with patients with mild intermittent asthma (126.0 +/- 8.8 and 131.9 +/- 7.1 versus 52.7 +/- 3.8 pg/ml, p < 0.001 and p < 0.0001) and normal subjects (126.0 +/- 8.8 and 131.9 +/- 7.1 versus 47.9 +/- 4.1 pg/ml, p < 0.0001). Elevated exhaled cys-LT levels were found in patients with mild and moderate to severe persistent asthma compared with normal subjects (27.9 +/- 2.8 and 31.5 +/- 4.5 versus 18.5 +/- 0.5 pg/ml, p < 0.01 and p < 0.05). There was an inverse correlation between exhaled cys-LTs and LTB4 in patients with mild persistent asthma. We conclude that exhaled cys-LTs and LTB4 may be noninvasive markers of airway inflammation in pediatric asthma. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12406853/Increased_leukotrienes_in_exhaled_breath_condensate_in_childhood_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200203-233OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -