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The burden of hepatitis C in the United States.
Hepatology 2002; 36(5 Suppl 1):S30-4Hep

Abstract

According to the third National Health and Nutrition Examination Survey (NHANES), 3.9 million of the U.S. civilian population have been infected with hepatitis C virus (HCV), of whom 2.7 million (74%) have chronic infection. Hepatitis C virus infection is most common among non-Caucasian men, ages 30 to 49 years. Moreover, the prevalence of antibody to hepatitis C virus in groups not represented in the NHANES sample, such as the homeless or incarcerated, may be as high as 40%. The age-adjusted death rate for non-A, non-B viral hepatitis increased from 0.4 to 1.8 deaths per 100,000 persons per year between 1982 and 1999. In 1999, the first year hepatitis C was reported separately, there were 3,759 deaths attributed to HCV, although this is likely an underestimate. There was a 5-fold increase in the annual number of patients with HCV who underwent liver transplantation between 1990 and 2000. Currently, more than one third of liver transplant candidates have HCV. Inpatient care of HCV-related liver disease has also been increasing. In 1998, an estimated 140,000 discharges listed an HCV-related diagnosis, accounting for 2% of discharges from non-federal acute care hospitals in the United States. The total direct health care cost associated with HCV is estimated to have exceeded $1 billion in 1998. Future projections predict a 4-fold increase between 1990 and 2015 in persons at risk of chronic liver disease (i.e., those with infection for 20 years or longer), suggesting a continued rise in the burden of HCV in the United States in the foreseeable future.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. kim.woong@mayo.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

12407574

Citation

Kim, W Ray. "The Burden of Hepatitis C in the United States." Hepatology (Baltimore, Md.), vol. 36, no. 5 Suppl 1, 2002, pp. S30-4.
Kim WR. The burden of hepatitis C in the United States. Hepatology. 2002;36(5 Suppl 1):S30-4.
Kim, W. R. (2002). The burden of hepatitis C in the United States. Hepatology (Baltimore, Md.), 36(5 Suppl 1), pp. S30-4.
Kim WR. The Burden of Hepatitis C in the United States. Hepatology. 2002;36(5 Suppl 1):S30-4. PubMed PMID: 12407574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The burden of hepatitis C in the United States. A1 - Kim,W Ray, PY - 2002/10/31/pubmed PY - 2002/11/28/medline PY - 2002/10/31/entrez SP - S30 EP - 4 JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 36 IS - 5 Suppl 1 N2 - According to the third National Health and Nutrition Examination Survey (NHANES), 3.9 million of the U.S. civilian population have been infected with hepatitis C virus (HCV), of whom 2.7 million (74%) have chronic infection. Hepatitis C virus infection is most common among non-Caucasian men, ages 30 to 49 years. Moreover, the prevalence of antibody to hepatitis C virus in groups not represented in the NHANES sample, such as the homeless or incarcerated, may be as high as 40%. The age-adjusted death rate for non-A, non-B viral hepatitis increased from 0.4 to 1.8 deaths per 100,000 persons per year between 1982 and 1999. In 1999, the first year hepatitis C was reported separately, there were 3,759 deaths attributed to HCV, although this is likely an underestimate. There was a 5-fold increase in the annual number of patients with HCV who underwent liver transplantation between 1990 and 2000. Currently, more than one third of liver transplant candidates have HCV. Inpatient care of HCV-related liver disease has also been increasing. In 1998, an estimated 140,000 discharges listed an HCV-related diagnosis, accounting for 2% of discharges from non-federal acute care hospitals in the United States. The total direct health care cost associated with HCV is estimated to have exceeded $1 billion in 1998. Future projections predict a 4-fold increase between 1990 and 2015 in persons at risk of chronic liver disease (i.e., those with infection for 20 years or longer), suggesting a continued rise in the burden of HCV in the United States in the foreseeable future. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/12407574/The_burden_of_hepatitis_C_in_the_United_States_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0270913902001696 DB - PRIME DP - Unbound Medicine ER -