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Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study.

Abstract

The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of valepotriates. Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week wash-out, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): valepotriates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and valepotriates groups showed a significant reduction in the psychic factor of HAM-A. The diazepam group also presented a significant reduction of the STAI-trait. Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted.

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  • Authors+Show Affiliations

    ,

    Departamento de Farmacologia, Laboratório de Fsisiologia e Farmacologia do Sistema Nervoso Central, Universidade Federal do Paraná, CP 19031, Curitiba, PR, Brazil, 81540-970. andreat@bio.ufpr.br

    , ,

    Source

    Phytotherapy research : PTR 16:7 2002 Nov pg 650-4

    MeSH

    Administration, Oral
    Adult
    Anti-Anxiety Agents
    Anxiety Disorders
    Diazepam
    Double-Blind Method
    Female
    Humans
    Iridoids
    Male
    Phytotherapy
    Pilot Projects
    Plant Extracts
    Severity of Illness Index
    Treatment Outcome
    Valerian

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12410546

    Citation

    Andreatini, Roberto, et al. "Effect of Valepotriates (valerian Extract) in Generalized Anxiety Disorder: a Randomized Placebo-controlled Pilot Study." Phytotherapy Research : PTR, vol. 16, no. 7, 2002, pp. 650-4.
    Andreatini R, Sartori VA, Seabra ML, et al. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother Res. 2002;16(7):650-4.
    Andreatini, R., Sartori, V. A., Seabra, M. L., & Leite, J. R. (2002). Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytotherapy Research : PTR, 16(7), pp. 650-4.
    Andreatini R, et al. Effect of Valepotriates (valerian Extract) in Generalized Anxiety Disorder: a Randomized Placebo-controlled Pilot Study. Phytother Res. 2002;16(7):650-4. PubMed PMID: 12410546.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. AU - Andreatini,Roberto, AU - Sartori,Vânia A, AU - Seabra,Maria L V, AU - Leite,José Roberto, PY - 2002/11/1/pubmed PY - 2003/3/21/medline PY - 2002/11/1/entrez SP - 650 EP - 4 JF - Phytotherapy research : PTR JO - Phytother Res VL - 16 IS - 7 N2 - The aim of the present study was to carry out a controlled pilot study on the putative anxiolytic effect of valepotriates. Thirty-six outpatients with generalized anxiety disorder (DSM III-R), after a 2-week wash-out, were randomized to one of the following three treatments for 4 weeks (n = 12 per group): valepotriates (mean daily dose: 81.3 mg), diazepam (mean daily dose: 6.5 mg), or placebo. A parallel, double-blind, flexible-dose, placebo-controlled design was employed. No significant difference was observed among the three groups at baseline or in the change from baseline on the Hamilton anxiety scale (HAM-A) or in the trait part of the state-trait anxiety inventory (STAI-trait). Moreover, the three groups presented a significant reduction in the total HAM-A scores. On the other hand, only the diazepam and valepotriates groups showed a significant reduction in the psychic factor of HAM-A. The diazepam group also presented a significant reduction of the STAI-trait. Although the principal analysis (HAM-A between group comparison) found negative results (probably due to the small sample size in each group), the preliminary data obtained in the present study suggest that the valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety. However, since the number of subjects per group was very small, the present results must be viewed as preliminary. Thus, further studies addressing this issue are warranted. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12410546/Effect_of_valepotriates__valerian_extract__in_generalized_anxiety_disorder:_a_randomized_placebo_controlled_pilot_study_ L2 - https://doi.org/10.1002/ptr.1027 DB - PRIME DP - Unbound Medicine ER -