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Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake.

Abstract

OBJECTIVE

To assess several lifestyle factors influencing benign prostatic enlargement and therefore the severity of benign prostatic hyperplasia (BPH).

SUBJECTS AND METHODS

In age-stratified cohorts from population-based random samples of 882 men (aged 65, 70, 75 and 80 years) each participant completed a standardized questionnaire, including weight, height, socio-economic status, use of cigarettes, alcohol and coffee consumption. The questionnaire also elicited detailed information on the medical history of prostatic and (over the past month) lower urinary tract symptoms, applying all questions from the American Urology Association instrument. The lifestyle variables were evaluated for confounding by multiple logistic regression, controlling for age, relative weight and professional education, with those classified as having BPH analysed as the dependent variable.

RESULTS

The prevalence of surgery for BPH increased with age from 15% at 65 years to 41% at 80 years. There was a strong inverse association between alcohol intake and men treated surgically for BPH or in 'watchful waiting' for surgical intervention, but a positive correlation with coffee consumption, and although not significantly, with the number of cigarettes smoked. Nevertheless, those who had never smoked have a slightly greater risk of BPH than current smokers. The body mass index and professional education were not associated with the risk of BPH.

CONCLUSIONS

Given the opposite effects of coffee and moderate alcohol consumption, together with the increased risk for clinical BPH in men with coronary heart disease, coffee constituents, which increase the serum concentration of low-density lipoprotein cholesterol, may be involved in the pathophysiology of BPH. Further epidemiological studies are needed to evaluate whether avoiding coffee intake reduces the risk of BPH.

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  • Authors+Show Affiliations

    Institute of Social and Preventive Medicine, Epidemiology, University of Zurich, Zurich, Switzerland. rgass@ifspm.unizh.ch

    Source

    BJU international 90:7 2002 Nov pg 649-54

    MeSH

    Aged
    Aged, 80 and over
    Alcohol Drinking
    Body Mass Index
    Coffee
    Humans
    Life Style
    Male
    Middle Aged
    Prostatic Hyperplasia
    Risk Factors
    Smoking

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    12410741

    Citation

    Gass, R. "Benign Prostatic Hyperplasia: the Opposite Effects of Alcohol and Coffee Intake." BJU International, vol. 90, no. 7, 2002, pp. 649-54.
    Gass R. Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake. BJU Int. 2002;90(7):649-54.
    Gass, R. (2002). Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake. BJU International, 90(7), pp. 649-54.
    Gass R. Benign Prostatic Hyperplasia: the Opposite Effects of Alcohol and Coffee Intake. BJU Int. 2002;90(7):649-54. PubMed PMID: 12410741.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake. A1 - Gass,R, PY - 2002/11/2/pubmed PY - 2002/12/17/medline PY - 2002/11/2/entrez SP - 649 EP - 54 JF - BJU international JO - BJU Int. VL - 90 IS - 7 N2 - OBJECTIVE: To assess several lifestyle factors influencing benign prostatic enlargement and therefore the severity of benign prostatic hyperplasia (BPH). SUBJECTS AND METHODS: In age-stratified cohorts from population-based random samples of 882 men (aged 65, 70, 75 and 80 years) each participant completed a standardized questionnaire, including weight, height, socio-economic status, use of cigarettes, alcohol and coffee consumption. The questionnaire also elicited detailed information on the medical history of prostatic and (over the past month) lower urinary tract symptoms, applying all questions from the American Urology Association instrument. The lifestyle variables were evaluated for confounding by multiple logistic regression, controlling for age, relative weight and professional education, with those classified as having BPH analysed as the dependent variable. RESULTS: The prevalence of surgery for BPH increased with age from 15% at 65 years to 41% at 80 years. There was a strong inverse association between alcohol intake and men treated surgically for BPH or in 'watchful waiting' for surgical intervention, but a positive correlation with coffee consumption, and although not significantly, with the number of cigarettes smoked. Nevertheless, those who had never smoked have a slightly greater risk of BPH than current smokers. The body mass index and professional education were not associated with the risk of BPH. CONCLUSIONS: Given the opposite effects of coffee and moderate alcohol consumption, together with the increased risk for clinical BPH in men with coronary heart disease, coffee constituents, which increase the serum concentration of low-density lipoprotein cholesterol, may be involved in the pathophysiology of BPH. Further epidemiological studies are needed to evaluate whether avoiding coffee intake reduces the risk of BPH. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/12410741/Benign_prostatic_hyperplasia:_the_opposite_effects_of_alcohol_and_coffee_intake_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1464-4096&date=2002&volume=90&issue=7&spage=649 DB - PRIME DP - Unbound Medicine ER -