Tags

Type your tag names separated by a space and hit enter

Is cardiovascular reactivity associated with atherosclerosis among hypertensives?
Hypertension 2002; 40(5):742-7H

Abstract

Exaggerated cardiovascular reactivity to behavioral challenges among otherwise healthy individuals has been associated with carotid atherosclerosis. We evaluated whether a similar relationship exists among hypertensives, who are at a heightened atherosclerotic risk. Untreated, hypertensive men (n=251; age range, 40 to 70 years; 197 white, 54 black) completed a standardized battery of behavioral challenges while their blood pressure responses to the battery were measured. Mean and maximum carotid intima-media thickness and the occurrence of carotid plaques were subsequently determined using B-mode ultrasonography. Although greater systolic and diastolic responses to the battery were associated with greater mean and maximum intima-media thickness in univariate analyses (P<0.01), only diastolic reactivity showed a unique association with mean and maximum carotid intima-media thickness after multivariate adjustment for age, race, socioeconomic status, smoking and alcohol use, body mass index, lipid profile, glucose and insulin concentrations, and resting blood pressure (P<0.05). Carotid plaque occurrence was associated with greater systolic reactivity (P=0.05) and was marginally associated with greater diastolic reactivity (P=0.07) in univariate analyses, but neither systolic nor diastolic reactivity was uniquely associated with the presence of carotid plaques after multivariate risk-factor adjustment. Among hypertensives, exaggerated behaviorally evoked cardiovascular reactivity appears to be uniquely associated with greater carotid intima-media thickness but not with carotid plaque occurrence.

Authors+Show Affiliations

Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pennsylvania, USA. gianarospj@msx.upmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12411471

Citation

Gianaros, Peter J., et al. "Is Cardiovascular Reactivity Associated With Atherosclerosis Among Hypertensives?" Hypertension (Dallas, Tex. : 1979), vol. 40, no. 5, 2002, pp. 742-7.
Gianaros PJ, Bleil ME, Muldoon MF, et al. Is cardiovascular reactivity associated with atherosclerosis among hypertensives? Hypertension. 2002;40(5):742-7.
Gianaros, P. J., Bleil, M. E., Muldoon, M. F., Jennings, J. R., Sutton-Tyrrell, K., McCaffery, J. M., & Manuck, S. B. (2002). Is cardiovascular reactivity associated with atherosclerosis among hypertensives? Hypertension (Dallas, Tex. : 1979), 40(5), pp. 742-7.
Gianaros PJ, et al. Is Cardiovascular Reactivity Associated With Atherosclerosis Among Hypertensives. Hypertension. 2002;40(5):742-7. PubMed PMID: 12411471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is cardiovascular reactivity associated with atherosclerosis among hypertensives? AU - Gianaros,Peter J, AU - Bleil,Maria E, AU - Muldoon,Matthew F, AU - Jennings,J Richard, AU - Sutton-Tyrrell,Kim, AU - McCaffery,Jeanne M, AU - Manuck,Stephen B, PY - 2002/11/2/pubmed PY - 2002/11/26/medline PY - 2002/11/2/entrez SP - 742 EP - 7 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 40 IS - 5 N2 - Exaggerated cardiovascular reactivity to behavioral challenges among otherwise healthy individuals has been associated with carotid atherosclerosis. We evaluated whether a similar relationship exists among hypertensives, who are at a heightened atherosclerotic risk. Untreated, hypertensive men (n=251; age range, 40 to 70 years; 197 white, 54 black) completed a standardized battery of behavioral challenges while their blood pressure responses to the battery were measured. Mean and maximum carotid intima-media thickness and the occurrence of carotid plaques were subsequently determined using B-mode ultrasonography. Although greater systolic and diastolic responses to the battery were associated with greater mean and maximum intima-media thickness in univariate analyses (P<0.01), only diastolic reactivity showed a unique association with mean and maximum carotid intima-media thickness after multivariate adjustment for age, race, socioeconomic status, smoking and alcohol use, body mass index, lipid profile, glucose and insulin concentrations, and resting blood pressure (P<0.05). Carotid plaque occurrence was associated with greater systolic reactivity (P=0.05) and was marginally associated with greater diastolic reactivity (P=0.07) in univariate analyses, but neither systolic nor diastolic reactivity was uniquely associated with the presence of carotid plaques after multivariate risk-factor adjustment. Among hypertensives, exaggerated behaviorally evoked cardiovascular reactivity appears to be uniquely associated with greater carotid intima-media thickness but not with carotid plaque occurrence. SN - 1524-4563 UR - https://www.unboundmedicine.com/medline/citation/12411471/Is_cardiovascular_reactivity_associated_with_atherosclerosis_among_hypertensives L2 - http://www.ahajournals.org/doi/full/10.1161/01.hyp.0000035707.57492.eb?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -