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Trace elements analysis of ascitic fluid in benign and malignant diseases.
Clin Biochem 2002; 35(6):477-81CB

Abstract

OBJECTIVES

To evaluate differences in ascitic fluid trace element concentrations which might be useful in discrimination between benign and malignant ascites.

DESIGN AND METHODS

The concentrations of copper, zinc, magnesium and iron in ascitic fluid and venous blood in 17 patients were investigated. The relationship between these trace elements and type of disease were examined. Investigations were carried out in a group of 5 males and 5 females aged 54 to 77 yr who had cirrhosis ascites and in a group of 7 females aged 41 to 76 yr with ascites due to gynecologic neoplasms.

RESULTS

The mean ascitic fluid and serum concentrations of copper were significantly higher in neoplastic diseases compared to benign disease states (118,43 vs. 97,50, 91,14 vs. 26.90) (p < 0,05 and p < 0,01 respectively). The zinc levels in ascitic fluid and serum were significantly different between the groups (p < 0,01). Neoplastic patients had significantly higher ascitic fluid magnesium levels than the benign disease group (2,17 vs. 1,55, p < 0,001). The serum levels of iron were significantly lower in the neoplastic diseases group (92, 28 vs. 255, p < 0, 01). In benign diseases the concentration of zinc in ascitic fluid correlated positively with ascitic fluid copper concentrations. The concentrations of zinc and iron in malignant ascites correlate positively with the magnesium concentrations. Statistically significant negative correlations were found between ascites zinc and magnesium and magnesium and copper in cirrhotic patients and magnesium and copper in malignant diseases.

CONCLUSIONS

The results showed that zinc, magnesium and iron levels were significantly different between cirrhotic and neoplastic illness. Analysis of serum and ascitic fluid trace element composition may be helpful in identifying and distinguishing the malignant and nonmalignant ascites and provides useful information on processes regulating passage of blood components into the peritoneal cavity.

Authors+Show Affiliations

Department of Biochemistry, Ege University School of Medicine, Bornova 35100 Izmir, Turkey. hcelik@med.ege.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12413609

Citation

Celik, Handan Ak, et al. "Trace Elements Analysis of Ascitic Fluid in Benign and Malignant Diseases." Clinical Biochemistry, vol. 35, no. 6, 2002, pp. 477-81.
Celik HA, Aydin HH, Ozsaran A, et al. Trace elements analysis of ascitic fluid in benign and malignant diseases. Clin Biochem. 2002;35(6):477-81.
Celik, H. A., Aydin, H. H., Ozsaran, A., Kilincsoy, N., Batur, Y., & Ersoz, B. (2002). Trace elements analysis of ascitic fluid in benign and malignant diseases. Clinical Biochemistry, 35(6), pp. 477-81.
Celik HA, et al. Trace Elements Analysis of Ascitic Fluid in Benign and Malignant Diseases. Clin Biochem. 2002;35(6):477-81. PubMed PMID: 12413609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace elements analysis of ascitic fluid in benign and malignant diseases. AU - Celik,Handan Ak, AU - Aydin,H Hakan, AU - Ozsaran,Aydin, AU - Kilincsoy,Nermin, AU - Batur,Yucel, AU - Ersoz,Biltan, PY - 2002/11/5/pubmed PY - 2003/12/19/medline PY - 2002/11/5/entrez SP - 477 EP - 81 JF - Clinical biochemistry JO - Clin. Biochem. VL - 35 IS - 6 N2 - OBJECTIVES: To evaluate differences in ascitic fluid trace element concentrations which might be useful in discrimination between benign and malignant ascites. DESIGN AND METHODS: The concentrations of copper, zinc, magnesium and iron in ascitic fluid and venous blood in 17 patients were investigated. The relationship between these trace elements and type of disease were examined. Investigations were carried out in a group of 5 males and 5 females aged 54 to 77 yr who had cirrhosis ascites and in a group of 7 females aged 41 to 76 yr with ascites due to gynecologic neoplasms. RESULTS: The mean ascitic fluid and serum concentrations of copper were significantly higher in neoplastic diseases compared to benign disease states (118,43 vs. 97,50, 91,14 vs. 26.90) (p < 0,05 and p < 0,01 respectively). The zinc levels in ascitic fluid and serum were significantly different between the groups (p < 0,01). Neoplastic patients had significantly higher ascitic fluid magnesium levels than the benign disease group (2,17 vs. 1,55, p < 0,001). The serum levels of iron were significantly lower in the neoplastic diseases group (92, 28 vs. 255, p < 0, 01). In benign diseases the concentration of zinc in ascitic fluid correlated positively with ascitic fluid copper concentrations. The concentrations of zinc and iron in malignant ascites correlate positively with the magnesium concentrations. Statistically significant negative correlations were found between ascites zinc and magnesium and magnesium and copper in cirrhotic patients and magnesium and copper in malignant diseases. CONCLUSIONS: The results showed that zinc, magnesium and iron levels were significantly different between cirrhotic and neoplastic illness. Analysis of serum and ascitic fluid trace element composition may be helpful in identifying and distinguishing the malignant and nonmalignant ascites and provides useful information on processes regulating passage of blood components into the peritoneal cavity. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/12413609/Trace_elements_analysis_of_ascitic_fluid_in_benign_and_malignant_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S000991200200334X DB - PRIME DP - Unbound Medicine ER -