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Clinical features of a young Japanese woman having marked obesity and abrupt onset of diabetes mellitus with ketoacidosis.
Diabetes Res Clin Pract 2002; 58(3):167-72DR

Abstract

The subject was a 26-year-old Japanese woman of 148 cm height, 96.2 kg of body weight (BW) (body mass index (BMI) of 43.8 kg/m(2)). She was referred to our hospital on May 1, 2000 for the evaluation of marked hyperglycemia with clinical symptom of general malaise, polydipsia, and ketonuria (3+). She did not smoke, or drink alcohol. But, she tended to eat lots of sweet food every day before the onset of this symptom. Her father was diagnosed type 2 diabetes mellitus. Her fasting plasma glucose and HbA(1c), and serum C-peptide were 398 mg/dl, 7.8% and less than 0.05 ng/ml [normal range: 0.94-2.8], respectively. She tested negative for anti-glutamic acid decarboxylase (GAD) antibodies and islet-cell antibodies. C-peptide level in her urine was as low as 3.4 microg/day. We immediately started insulin treatment under the diagnosis of abrupt onset of diabetes mellitus with diabetic ketoacidosis on the day of her admission, and the insulin treatment was continued after her being discharged. She showed continuous BW reduction until her BW reached approximately 60 kg, followed by her BW being plateau. During the period, intra-abdominal visceral fat (VF) and subcutaneous fat (SF) volume assessed by helical computerized tomography (CT) showed a substantial reduction [3.9-0.5 l for VF, 19-3.2 l for SF volume]. Pre-heparin plasma lipoprotein lipase (LPL) mass showed a considerably lower value when she had continuous BW reduction than did it when her BW reduction discontinued. These findings suggest that in this subject, continuous BW reduction after the abrupt onset of diabetes is closely associated with intra-abdominal fat mass reduction, which may be related to decreased production of LPL.

Authors+Show Affiliations

Department of Internal Medicine, Chibaken Saiseikai Narashino Hospital, 1-1-1 Izumicho, Narishino City, Chiba Prefecture, 275-0006, Japan. maryland95@angel.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12413775

Citation

Kobayashi, Junji, et al. "Clinical Features of a Young Japanese Woman Having Marked Obesity and Abrupt Onset of Diabetes Mellitus With Ketoacidosis." Diabetes Research and Clinical Practice, vol. 58, no. 3, 2002, pp. 167-72.
Kobayashi J, Sasaki T, Ishiba Y, et al. Clinical features of a young Japanese woman having marked obesity and abrupt onset of diabetes mellitus with ketoacidosis. Diabetes Res Clin Pract. 2002;58(3):167-72.
Kobayashi, J., Sasaki, T., Ishiba, Y., & Watanabe, M. (2002). Clinical features of a young Japanese woman having marked obesity and abrupt onset of diabetes mellitus with ketoacidosis. Diabetes Research and Clinical Practice, 58(3), pp. 167-72.
Kobayashi J, et al. Clinical Features of a Young Japanese Woman Having Marked Obesity and Abrupt Onset of Diabetes Mellitus With Ketoacidosis. Diabetes Res Clin Pract. 2002;58(3):167-72. PubMed PMID: 12413775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of a young Japanese woman having marked obesity and abrupt onset of diabetes mellitus with ketoacidosis. AU - Kobayashi,Junji, AU - Sasaki,Takeyoshi, AU - Ishiba,Yasuko, AU - Watanabe,Mitsuyo, PY - 2002/11/5/pubmed PY - 2003/5/15/medline PY - 2002/11/5/entrez SP - 167 EP - 72 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 58 IS - 3 N2 - The subject was a 26-year-old Japanese woman of 148 cm height, 96.2 kg of body weight (BW) (body mass index (BMI) of 43.8 kg/m(2)). She was referred to our hospital on May 1, 2000 for the evaluation of marked hyperglycemia with clinical symptom of general malaise, polydipsia, and ketonuria (3+). She did not smoke, or drink alcohol. But, she tended to eat lots of sweet food every day before the onset of this symptom. Her father was diagnosed type 2 diabetes mellitus. Her fasting plasma glucose and HbA(1c), and serum C-peptide were 398 mg/dl, 7.8% and less than 0.05 ng/ml [normal range: 0.94-2.8], respectively. She tested negative for anti-glutamic acid decarboxylase (GAD) antibodies and islet-cell antibodies. C-peptide level in her urine was as low as 3.4 microg/day. We immediately started insulin treatment under the diagnosis of abrupt onset of diabetes mellitus with diabetic ketoacidosis on the day of her admission, and the insulin treatment was continued after her being discharged. She showed continuous BW reduction until her BW reached approximately 60 kg, followed by her BW being plateau. During the period, intra-abdominal visceral fat (VF) and subcutaneous fat (SF) volume assessed by helical computerized tomography (CT) showed a substantial reduction [3.9-0.5 l for VF, 19-3.2 l for SF volume]. Pre-heparin plasma lipoprotein lipase (LPL) mass showed a considerably lower value when she had continuous BW reduction than did it when her BW reduction discontinued. These findings suggest that in this subject, continuous BW reduction after the abrupt onset of diabetes is closely associated with intra-abdominal fat mass reduction, which may be related to decreased production of LPL. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/12413775/Clinical_features_of_a_young_Japanese_woman_having_marked_obesity_and_abrupt_onset_of_diabetes_mellitus_with_ketoacidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168822702001572 DB - PRIME DP - Unbound Medicine ER -