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Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC.
Psychopharmacol Commun. 1975; 1(3):275-83.PC

Abstract

Racemic methadone hydrochloride was administered to male rats in daily subcutaneous injections of 10-30 mg/kg. Dependence, when assessed by naloxone challenge after 26 days, was quantitatively and qualitatively similar to that previously reported by us for rats implanted with a 75 mg morphine pellet for 72 hours. Abstinence scores in animals pretreated acutely with 10 mg/kg delta 9-THC one hour before naloxone were significantly less than those of a vehicle control group, and wet shakes and gastrointestinal signs of abstinence were blocked. These results extend previous observations of morphine abstinence attenuating properties of delta 9-THC to effects on animals dependent on methadone.

Authors

Hine B
No affiliation info available
Torrelio M
No affiliation info available
Gershon S
No affiliation info available

MeSH

AnimalsBehavior, AnimalCannabisDronabinolDrug ToleranceHumansMaleMethadoneMorphine DependenceNaloxonePhytotherapyRatsSubstance Withdrawal SyndromeSubstance-Related Disorders

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1241452

Citation

Hine, B, et al. "Attenuation of Precipitated Abstinence in Methadone-dependent Rats By Delta 9-THC." Psychopharmacology Communications, vol. 1, no. 3, 1975, pp. 275-83.
Hine B, Torrelio M, Gershon S. Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC. Psychopharmacol Commun. 1975;1(3):275-83.
Hine, B., Torrelio, M., & Gershon, S. (1975). Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC. Psychopharmacology Communications, 1(3), 275-83.
Hine B, Torrelio M, Gershon S. Attenuation of Precipitated Abstinence in Methadone-dependent Rats By Delta 9-THC. Psychopharmacol Commun. 1975;1(3):275-83. PubMed PMID: 1241452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC. AU - Hine,B, AU - Torrelio,M, AU - Gershon,S, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 275 EP - 83 JF - Psychopharmacology communications JO - Psychopharmacol Commun VL - 1 IS - 3 N2 - Racemic methadone hydrochloride was administered to male rats in daily subcutaneous injections of 10-30 mg/kg. Dependence, when assessed by naloxone challenge after 26 days, was quantitatively and qualitatively similar to that previously reported by us for rats implanted with a 75 mg morphine pellet for 72 hours. Abstinence scores in animals pretreated acutely with 10 mg/kg delta 9-THC one hour before naloxone were significantly less than those of a vehicle control group, and wet shakes and gastrointestinal signs of abstinence were blocked. These results extend previous observations of morphine abstinence attenuating properties of delta 9-THC to effects on animals dependent on methadone. SN - 0098-616X UR - https://www.unboundmedicine.com/medline/citation/1241452/Attenuation_of_precipitated_abstinence_in_methadone_dependent_rats_by_delta_9_THC_ DB - PRIME DP - Unbound Medicine ER -