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Endoscopic mucosal resection for advanced non-polypoid colorectal adenoma and early stage carcinoma.
Surg Endosc. 2003 Mar; 17(3):475-9.SE

Abstract

PURPOSE

Endoscopic mucosal resection (EMR) techniques were evaluated in the treatment of flat and sessile colorectal neoplasm.

PATIENTS AND METHODS

Fifty-seven patients (32 female, 25 male) with non-polypoid colorectal lesions (n = 71, size >or= 10 mm) were included in the study. Tumor location, shape, size, and depth (in malignant lesions) were determined by endoscopy and endoscopic ultrasound. EMR was performed using snare resection, endoscopic aspiration mucosectomy, or EMR using a cap-fitted endoscope.

RESULTS

Lesion size ranged from 10 to 50 mm. Complete resection was achieved in 59 of 61 benign and 6 of 8 malignant tumors. Thirty-five tumors were excised in one segment and 34 tumors in piecemeal technique. Pathological examination of neoplasm treated by EMR showed adenoma in 61 and early-stage carcinoma in 8 cases. Because of the non-lifting sign, 2 of 71 tumors were not treated endoscopically and referred to surgical resection revealing a T2 adenocarcinoma in both cases. Resection was incomplete in 2 of 61 adenomas with histological positive resection margin. Complications occurred in 2 patients, with 1 bleeding treated endoscopically and 1 perforation treated by surgery. Local recurrence was observed in 2 of 59 completely resected adenomas and in none of 6 early-stage carcinomas during a mean follow-up of 18 months (range 6 to 30 months).

CONCLUSION

Advanced non-polypoid colorectal adenomas and early-stage carcinomas can be safely and effectively resected by endoscopic mucosal resection.

Authors+Show Affiliations

Bergmann U
Department of General Surgery, University Clinic Ulm, Ulm, Germany. C-U-Mail@t-online.de
Beger HG
No affiliation info available

MeSH

AdenomaCarcinomaCecal NeoplasmsColonic NeoplasmsColorectal NeoplasmsEndoscopy, GastrointestinalFemaleHumansMaleMiddle AgedRectal NeoplasmsSigmoid Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12415335

Citation

Bergmann, U, and H G. Beger. "Endoscopic Mucosal Resection for Advanced Non-polypoid Colorectal Adenoma and Early Stage Carcinoma." Surgical Endoscopy, vol. 17, no. 3, 2003, pp. 475-9.
Bergmann U, Beger HG. Endoscopic mucosal resection for advanced non-polypoid colorectal adenoma and early stage carcinoma. Surg Endosc. 2003;17(3):475-9.
Bergmann, U., & Beger, H. G. (2003). Endoscopic mucosal resection for advanced non-polypoid colorectal adenoma and early stage carcinoma. Surgical Endoscopy, 17(3), 475-9.
Bergmann U, Beger HG. Endoscopic Mucosal Resection for Advanced Non-polypoid Colorectal Adenoma and Early Stage Carcinoma. Surg Endosc. 2003;17(3):475-9. PubMed PMID: 12415335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic mucosal resection for advanced non-polypoid colorectal adenoma and early stage carcinoma. AU - Bergmann,U, AU - Beger,H G, Y1 - 2002/11/06/ PY - 2002/07/08/received PY - 2002/07/31/accepted PY - 2002/11/5/pubmed PY - 2003/5/7/medline PY - 2002/11/5/entrez SP - 475 EP - 9 JF - Surgical endoscopy JO - Surg Endosc VL - 17 IS - 3 N2 - PURPOSE: Endoscopic mucosal resection (EMR) techniques were evaluated in the treatment of flat and sessile colorectal neoplasm. PATIENTS AND METHODS: Fifty-seven patients (32 female, 25 male) with non-polypoid colorectal lesions (n = 71, size >or= 10 mm) were included in the study. Tumor location, shape, size, and depth (in malignant lesions) were determined by endoscopy and endoscopic ultrasound. EMR was performed using snare resection, endoscopic aspiration mucosectomy, or EMR using a cap-fitted endoscope. RESULTS: Lesion size ranged from 10 to 50 mm. Complete resection was achieved in 59 of 61 benign and 6 of 8 malignant tumors. Thirty-five tumors were excised in one segment and 34 tumors in piecemeal technique. Pathological examination of neoplasm treated by EMR showed adenoma in 61 and early-stage carcinoma in 8 cases. Because of the non-lifting sign, 2 of 71 tumors were not treated endoscopically and referred to surgical resection revealing a T2 adenocarcinoma in both cases. Resection was incomplete in 2 of 61 adenomas with histological positive resection margin. Complications occurred in 2 patients, with 1 bleeding treated endoscopically and 1 perforation treated by surgery. Local recurrence was observed in 2 of 59 completely resected adenomas and in none of 6 early-stage carcinomas during a mean follow-up of 18 months (range 6 to 30 months). CONCLUSION: Advanced non-polypoid colorectal adenomas and early-stage carcinomas can be safely and effectively resected by endoscopic mucosal resection. SN - 1432-2218 UR - https://www.unboundmedicine.com/medline/citation/12415335/Endoscopic_mucosal_resection_for_advanced_non_polypoid_colorectal_adenoma_and_early_stage_carcinoma_ DB - PRIME DP - Unbound Medicine ER -