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Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats.
Pediatr Surg Int. 2002 Sep; 18(5-6):332-6.PS

Abstract

To evaluate whether L-arginine methyl ester (L-Arg) can improve the structure of the small intestine and enhance adaptation in an experimental model of short-bowel syndrome (SBS), 40 Sprague-Dawley rats were divided randomly into four groups of 10 each. In one group only a laparotomy was performed (G1). The remaining 30 rats underwent 90% small-bowel resection (SBR) and formed the three experimental groups: the SBR/untreated group (G2), the SBR/L-NAME-treated group (G3), and the SBR/ L-Arg-treated group (G4). Rats in G2 received no therapeutic treatment. Rats in the SBR/L-NAME and SBR/L-Arg treated groups received N-G-nitro-L-arginine-methyl ester (L-NAME) and L-Arg intraperitoneally for 3 weeks, respectively. The animals were weighed daily. All rats underwent a relaparotomy on day 21 of the experiment. Remnant small bowel was excised and evaluated for villus height and crypt cell mitoses. After the 90% SBR, all animals had from diarrhea and weight loss between the 1st and 6th postoperative days (POD). The body weight of the SBR/L-Arg group showed significant increases at POD 10 and 21 in comparison to the SBR/untreated and SBR/L-NAME groups (P < 0.001). The rats treated with L-Arg had significantly greater villus height and crypt-cell mitoses compared to the other groups (P < 0.0001, P < 0.001). These observations suggest that L-Arg treatment increases villus height and crypt-cell mitoses after massive SBR and may play a considerable role in the mucosal adaptive response in SBS in rats.

Authors+Show Affiliations

Dicle University Medical School, Department of Pediatric Surgery, 21280 Diyarbakir, Turkey. ozturkhayrettin@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

12415349

Citation

Oztürk, Hayrettin, et al. "Effects of Supplemental L-arginine On the Intestinal Adaptive Response After Massive Small-bowel Resection in Rats." Pediatric Surgery International, vol. 18, no. 5-6, 2002, pp. 332-6.
Oztürk H, Dokucu AI, Yağmur Y, et al. Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats. Pediatr Surg Int. 2002;18(5-6):332-6.
Oztürk, H., Dokucu, A. I., Yağmur, Y., & Sari, I. (2002). Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats. Pediatric Surgery International, 18(5-6), 332-6.
Oztürk H, et al. Effects of Supplemental L-arginine On the Intestinal Adaptive Response After Massive Small-bowel Resection in Rats. Pediatr Surg Int. 2002;18(5-6):332-6. PubMed PMID: 12415349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplemental L-arginine on the intestinal adaptive response after massive small-bowel resection in rats. AU - Oztürk,Hayrettin, AU - Dokucu,Ali Ihsan, AU - Yağmur,Yusuf, AU - Sari,Ibrahim, Y1 - 2002/05/09/ PY - 2001/12/09/accepted PY - 2002/11/5/pubmed PY - 2003/3/22/medline PY - 2002/11/5/entrez SP - 332 EP - 6 JF - Pediatric surgery international JO - Pediatr Surg Int VL - 18 IS - 5-6 N2 - To evaluate whether L-arginine methyl ester (L-Arg) can improve the structure of the small intestine and enhance adaptation in an experimental model of short-bowel syndrome (SBS), 40 Sprague-Dawley rats were divided randomly into four groups of 10 each. In one group only a laparotomy was performed (G1). The remaining 30 rats underwent 90% small-bowel resection (SBR) and formed the three experimental groups: the SBR/untreated group (G2), the SBR/L-NAME-treated group (G3), and the SBR/ L-Arg-treated group (G4). Rats in G2 received no therapeutic treatment. Rats in the SBR/L-NAME and SBR/L-Arg treated groups received N-G-nitro-L-arginine-methyl ester (L-NAME) and L-Arg intraperitoneally for 3 weeks, respectively. The animals were weighed daily. All rats underwent a relaparotomy on day 21 of the experiment. Remnant small bowel was excised and evaluated for villus height and crypt cell mitoses. After the 90% SBR, all animals had from diarrhea and weight loss between the 1st and 6th postoperative days (POD). The body weight of the SBR/L-Arg group showed significant increases at POD 10 and 21 in comparison to the SBR/untreated and SBR/L-NAME groups (P < 0.001). The rats treated with L-Arg had significantly greater villus height and crypt-cell mitoses compared to the other groups (P < 0.0001, P < 0.001). These observations suggest that L-Arg treatment increases villus height and crypt-cell mitoses after massive SBR and may play a considerable role in the mucosal adaptive response in SBS in rats. SN - 0179-0358 UR - https://www.unboundmedicine.com/medline/citation/12415349/Effects_of_supplemental_L_arginine_on_the_intestinal_adaptive_response_after_massive_small_bowel_resection_in_rats_ L2 - https://doi.org/10.1007/s00383-002-0836-x DB - PRIME DP - Unbound Medicine ER -