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[High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City].
Rev Invest Clin 2002 Jul-Aug; 54(4):299-306RI

Abstract

OBJECTIVE

To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City.

MATERIAL AND METHODS

Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done.

RESULTS

One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree.

CONCLUSIONS

The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer.

Authors+Show Affiliations

Unidad de Investigación Médica en Enfermedades Oncológicas, Servicio de Patología, Hospital de Oncología, CMN Siglo XXI, IMSS. dulcema@servidor.unam.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

12415953

Citation

Hernández-Hernández, Dulce Ma, et al. "[High-risk Human Papilloma Virus and Cervical Intraepithelial Neoplasia in Women at 2 Hospitals in Mexico City]." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 54, no. 4, 2002, pp. 299-306.
Hernández-Hernández DM, García-Carrancá A, Guido-Jiménez MC, et al. [High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City]. Rev Invest Clin. 2002;54(4):299-306.
Hernández-Hernández, D. M., García-Carrancá, A., Guido-Jiménez, M. C., González-Sánchez, J. L., Cruz-Talonia, F., Apresa-García, T., ... Muñoz, S. (2002). [High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City]. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 54(4), pp. 299-306.
Hernández-Hernández DM, et al. [High-risk Human Papilloma Virus and Cervical Intraepithelial Neoplasia in Women at 2 Hospitals in Mexico City]. Rev Invest Clin. 2002;54(4):299-306. PubMed PMID: 12415953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [High-risk human papilloma virus and cervical intraepithelial neoplasia in women at 2 hospitals in Mexico City]. AU - Hernández-Hernández,Dulce Ma, AU - García-Carrancá,Alejandro, AU - Guido-Jiménez,Miriam C, AU - González-Sánchez,José Luis, AU - Cruz-Talonia,Fernando, AU - Apresa-García,Teresa, AU - Martínez-Elizondo,Olga A, AU - Ornelas-Bernal,Laura, AU - Alvarado-Cabrera,Isabel, AU - Muñoz,Sergio, PY - 2002/11/6/pubmed PY - 2003/1/24/medline PY - 2002/11/6/entrez SP - 299 EP - 306 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev. Invest. Clin. VL - 54 IS - 4 N2 - OBJECTIVE: To determine the high risk HPV (HR-HPV) association with Cervical Intraepithelial Neoplasia (CIN) in women of two Dysplasia Clinics in Mexico City. MATERIAL AND METHODS: Prolective case-control study was done. Women with and without security affiliation attended in Instituto Mexicano del Seguro Social (Hospital 1) and Hospital General de México (Hospital 2) were included in the study. Cases were women with histopathologic diagnosis of CIN and controls were women with negative dysplasia in cytologic study (Pap). Information was obtained by direct interview. HR-HPV was determined by Hybrid Capture II assay, in cervical samples. Bivariate and logistic regression analysis was done. RESULTS: One hundred and two cases and 192 controls from Hospital 1 and 89 cases and 66 controls from Hospital 2 were included. 83.3% and 77.3% of women from Hospital 1 and 2 respectively were positive to HR-HPV. The association HR-HPV and CIN in Hospital 1 was ORa = 40.6, C.I. 95% = 17-96.8; while in Hospital 2 there was not association. Age was an effect modifier in the HR-HVP and CIN association, in Hospital 1. It was observed a correlation between viral load and CIN degree. CONCLUSIONS: The HR-HPV infection frequency in controls and CIN I was higher than the reported in other studies. Age was a modifier in the HR-HPV association and CIN. In dysplasia clinics without medical referral system of patients is possible to observe similar risk factors to cervical cancer. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/12415953/[High_risk_human_papilloma_virus_and_cervical_intraepithelial_neoplasia_in_women_at_2_hospitals_in_Mexico_City]_ L2 - http://www.diseaseinfosearch.org/result/1266 DB - PRIME DP - Unbound Medicine ER -