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Dietary carotenoid intake and colorectal cancer risk.
Nutr Cancer. 2002; 42(2):167-72.NC

Abstract

Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than beta-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of beta-carotene, alpha-carotene, lycopene, lutein, and beta-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted.

Authors+Show Affiliations

Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. pterry@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12416255

Citation

Terry, Paul, et al. "Dietary Carotenoid Intake and Colorectal Cancer Risk." Nutrition and Cancer, vol. 42, no. 2, 2002, pp. 167-72.
Terry P, Jain M, Miller AB, et al. Dietary carotenoid intake and colorectal cancer risk. Nutr Cancer. 2002;42(2):167-72.
Terry, P., Jain, M., Miller, A. B., Howe, G. R., & Rohan, T. E. (2002). Dietary carotenoid intake and colorectal cancer risk. Nutrition and Cancer, 42(2), 167-72.
Terry P, et al. Dietary Carotenoid Intake and Colorectal Cancer Risk. Nutr Cancer. 2002;42(2):167-72. PubMed PMID: 12416255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary carotenoid intake and colorectal cancer risk. AU - Terry,Paul, AU - Jain,Meera, AU - Miller,Anthony B, AU - Howe,Geoffrey R, AU - Rohan,Thomas E, PY - 2002/11/6/pubmed PY - 2003/2/14/medline PY - 2002/11/6/entrez SP - 167 EP - 72 JF - Nutrition and cancer JO - Nutr Cancer VL - 42 IS - 2 N2 - Several studies have found inverse associations between fruit and vegetable consumption and colorectal cancer risk, suggesting the potential etiological importance of carotenoids (and other phytochemicals) contained in these foods. However, only one study (a case-control study) has examined the association between dietary carotenoids other than beta-carotene and colorectal cancer risk. In the study reported here, we examined the relationships between dietary intakes of beta-carotene, alpha-carotene, lycopene, lutein, and beta-cryptoxanthin and colorectal cancer risk in a large cohort study of Canadian women. A case-cohort analysis was undertaken within the cohort of 56,837 women who were enrolled in the Canadian National Breast Screening Study and who completed a self-administered dietary questionnaire. During follow-up to the end of 1993, a total of 388 women were diagnosed with colorectal cancer. For comparative purposes, a subcohort of 5,681 women was randomly selected. After exclusions for various reasons, the analyses were based on 295 cases and 5,334 noncases. We did not find any clear association between intake of any of the studied carotenoids and colorectal cancer risk in the study population as a whole or in subgroups defined by smoking status, relative body weight (body mass index), intakes of total fat, energy, alcohol, and folic acid, or menopausal status. Our data do not support any association between dietary intakes of the studied carotenoids and colorectal cancer risk. However, given that this is the first prospective cohort study of carotenoids in relation to colorectal cancer, further studies are warranted. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/12416255/Dietary_carotenoid_intake_and_colorectal_cancer_risk_ L2 - https://www.tandfonline.com/doi/full/10.1207/S15327914NC422_3 DB - PRIME DP - Unbound Medicine ER -