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Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome. A case report.
J Reprod Med. 2002 Oct; 47(10):875-7.JR

Abstract

BACKGROUND

The syndrome of hemolytic anemia, elevated liver enzymes and low platelets (HELLP) can accompany preeclampsia and eclampsia. Delivery of the infant usually results in improvement in the mother's condition, with the recovery time dependent on the severity of the disease. We report a case of eclampsia with the HELLP syndrome in which microangiopathic hemolytic anemia (MAHA) and thrombocytopenia recurred after apparent recovery.

CASE

A 28-year-old woman, gravida 4, para 0, therapeutic abortion 3, presented with signs and symptoms of severe preeclampsia and became eclamptic. The patient's condition improved as expected following cesarean delivery. However, the hemolytic anemia recurred and was successfully treated with a course of fresh frozen plasma (FFP).

CONCLUSION

Hemolytic anemia in women with eclampsia and the HELLP syndrome occurs secondary to microvascular endothelial damage. In this case resolution of the HELLP syndrome and eclampsia occurred, as expected, in two to three days; however, MAHA and low platelets recurred on day 4. Treatment of MAHA with FFP was successful.

Authors+Show Affiliations

Departments of Obstetrics and Gynecology, Medicine and Microbiology, Center for Molecular Biology, Loma Linda University Medical Center, Loma Linda, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12418076

Citation

Lombano, Frank, et al. "Recurrence of Microangiopathic Hemolytic Anemia After Apparent Recovery From the HELLP Syndrome. a Case Report." The Journal of Reproductive Medicine, vol. 47, no. 10, 2002, pp. 875-7.
Lombano F, Kidder MY, Lilly M, et al. Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome. A case report. J Reprod Med. 2002;47(10):875-7.
Lombano, F., Kidder, M. Y., Lilly, M., Gollin, Y. G., & Block, B. S. (2002). Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome. A case report. The Journal of Reproductive Medicine, 47(10), 875-7.
Lombano F, et al. Recurrence of Microangiopathic Hemolytic Anemia After Apparent Recovery From the HELLP Syndrome. a Case Report. J Reprod Med. 2002;47(10):875-7. PubMed PMID: 12418076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrence of microangiopathic hemolytic anemia after apparent recovery from the HELLP syndrome. A case report. AU - Lombano,Frank, AU - Kidder,Melissa Y, AU - Lilly,Michael, AU - Gollin,Yvonne G, AU - Block,Barry S, PY - 2002/11/7/pubmed PY - 2003/2/13/medline PY - 2002/11/7/entrez SP - 875 EP - 7 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 47 IS - 10 N2 - BACKGROUND: The syndrome of hemolytic anemia, elevated liver enzymes and low platelets (HELLP) can accompany preeclampsia and eclampsia. Delivery of the infant usually results in improvement in the mother's condition, with the recovery time dependent on the severity of the disease. We report a case of eclampsia with the HELLP syndrome in which microangiopathic hemolytic anemia (MAHA) and thrombocytopenia recurred after apparent recovery. CASE: A 28-year-old woman, gravida 4, para 0, therapeutic abortion 3, presented with signs and symptoms of severe preeclampsia and became eclamptic. The patient's condition improved as expected following cesarean delivery. However, the hemolytic anemia recurred and was successfully treated with a course of fresh frozen plasma (FFP). CONCLUSION: Hemolytic anemia in women with eclampsia and the HELLP syndrome occurs secondary to microvascular endothelial damage. In this case resolution of the HELLP syndrome and eclampsia occurred, as expected, in two to three days; however, MAHA and low platelets recurred on day 4. Treatment of MAHA with FFP was successful. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/12418076/Recurrence_of_microangiopathic_hemolytic_anemia_after_apparent_recovery_from_the_HELLP_syndrome__A_case_report_ L2 - https://www.diseaseinfosearch.org/result/3266 DB - PRIME DP - Unbound Medicine ER -