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Circadian heart rate variability in Parkinson's disease.
J Neurol. 2002 Nov; 249(11):1535-40.JN

Abstract

Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited. We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects.In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD(1) value of the Poincaré two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincaré was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls. The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night.

Authors+Show Affiliations

Department of Neurology, University of Oulu, P. O. Box 5000, 90014 Oulu, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12420094

Citation

Pursiainen, Ville, et al. "Circadian Heart Rate Variability in Parkinson's Disease." Journal of Neurology, vol. 249, no. 11, 2002, pp. 1535-40.
Pursiainen V, Haapaniemi TH, Korpelainen JT, et al. Circadian heart rate variability in Parkinson's disease. J Neurol. 2002;249(11):1535-40.
Pursiainen, V., Haapaniemi, T. H., Korpelainen, J. T., Huikuri, H. V., Sotaniemi, K. A., & Myllylä, V. V. (2002). Circadian heart rate variability in Parkinson's disease. Journal of Neurology, 249(11), 1535-40.
Pursiainen V, et al. Circadian Heart Rate Variability in Parkinson's Disease. J Neurol. 2002;249(11):1535-40. PubMed PMID: 12420094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian heart rate variability in Parkinson's disease. AU - Pursiainen,Ville, AU - Haapaniemi,Tarja H, AU - Korpelainen,Juha T, AU - Huikuri,Heikki V, AU - Sotaniemi,Kyösti A, AU - Myllylä,Vilho V, PY - 2002/11/7/pubmed PY - 2003/4/11/medline PY - 2002/11/7/entrez SP - 1535 EP - 40 JF - Journal of neurology JO - J Neurol VL - 249 IS - 11 N2 - Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited. We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects.In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD(1) value of the Poincaré two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincaré was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls. The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night. SN - 0340-5354 UR - https://www.unboundmedicine.com/medline/citation/12420094/Circadian_heart_rate_variability_in_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00415-002-0884-0 DB - PRIME DP - Unbound Medicine ER -