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[Helicobacter pylori infection in gastric cancer patients].
Pol Merkur Lekarski 2002; 13(74):103-6PM

Abstract

The aim of the study was to evaluate the role of Helicobacter pylori infection in gastric cancer development.

MATERIAL AND METHODS

475 patients were included into the study (270 gastric cancer patients and 205 controls). Helicobacter pylori status was determined by enzyme linked immunoabsorbent assay (ELISA). The frequency of H. pylori infection in gastric cancer patients and the control group was compared. The relationship between the presence of anti-H. pylori antibodies and selected clinical and pathomorphological parameters was analysed.

RESULTS

H. pylori infection was statistically more frequent in gastric cancer patients than in controls (94.4% vs. 86.3%, p = 0.0039). Subjects infected with H. pylori were about 2.5-fold more likely to develop gastric cancer than uninfected individuals (OR = 2.69; 95% CI = 0.93-4.45) and the risk depended on age. A positive relationship between H. pylori infection and family history of cancer was found (p = 0.045). H. pylori status was irrespective of patient's age, sex, duration of symptoms, AB0 blood group, tumour site, stage, histology and p53 status in cancer tissue.

CONCLUSION

Our study confirms a positive relationship between H. pylori infection and gastric cancer, however, in contrast to previous reports fails to demonstrate that bacteria protect the host from cardia cancer. Our results suggest also that in gastric cancer H. pylori does not induce p53 mutations.

Authors+Show Affiliations

Klinika Gastroenterologii PAM w Szczecinie.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

12420337

Citation

Ławniczak, Malgorzata, and Teresa Starzyńska. "[Helicobacter Pylori Infection in Gastric Cancer Patients]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 13, no. 74, 2002, pp. 103-6.
Ławniczak M, Starzyńska T. [Helicobacter pylori infection in gastric cancer patients]. Pol Merkur Lekarski. 2002;13(74):103-6.
Ławniczak, M., & Starzyńska, T. (2002). [Helicobacter pylori infection in gastric cancer patients]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 13(74), pp. 103-6.
Ławniczak M, Starzyńska T. [Helicobacter Pylori Infection in Gastric Cancer Patients]. Pol Merkur Lekarski. 2002;13(74):103-6. PubMed PMID: 12420337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Helicobacter pylori infection in gastric cancer patients]. AU - Ławniczak,Malgorzata, AU - Starzyńska,Teresa, PY - 2002/11/8/pubmed PY - 2002/12/17/medline PY - 2002/11/8/entrez SP - 103 EP - 6 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 13 IS - 74 N2 - UNLABELLED: The aim of the study was to evaluate the role of Helicobacter pylori infection in gastric cancer development. MATERIAL AND METHODS: 475 patients were included into the study (270 gastric cancer patients and 205 controls). Helicobacter pylori status was determined by enzyme linked immunoabsorbent assay (ELISA). The frequency of H. pylori infection in gastric cancer patients and the control group was compared. The relationship between the presence of anti-H. pylori antibodies and selected clinical and pathomorphological parameters was analysed. RESULTS: H. pylori infection was statistically more frequent in gastric cancer patients than in controls (94.4% vs. 86.3%, p = 0.0039). Subjects infected with H. pylori were about 2.5-fold more likely to develop gastric cancer than uninfected individuals (OR = 2.69; 95% CI = 0.93-4.45) and the risk depended on age. A positive relationship between H. pylori infection and family history of cancer was found (p = 0.045). H. pylori status was irrespective of patient's age, sex, duration of symptoms, AB0 blood group, tumour site, stage, histology and p53 status in cancer tissue. CONCLUSION: Our study confirms a positive relationship between H. pylori infection and gastric cancer, however, in contrast to previous reports fails to demonstrate that bacteria protect the host from cardia cancer. Our results suggest also that in gastric cancer H. pylori does not induce p53 mutations. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/12420337/[Helicobacter_pylori_infection_in_gastric_cancer_patients]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -