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Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.
Free Radic Res. 2002 Aug; 36(8):923-8.FR

Abstract

Tetrahydro-beta-carboline alkaloids that occur in foods such as wine, seasonings, vinegar and fruit products juices, jams) acted as good radical scavengers (hydrogen- or electron donating) in the ABTS (2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay, and therefore, they could contribute to the beneficial antioxidant capacity attributed to foods. In contrast, the fully aromatic beta-carbolines norharman and harman did not show any radical scavenger activity in the same assay. During the reaction with ABTS.+ radical cation, tetrahydro-beta-carboline-3-carboxylic acid such as 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline-1,3-dicarboxylic acid (MTCA-COOH) were converted to harman, whereas 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (THCA) and 1,2,3,4-tetrahydro-beta-carboline-1,3-dicarboxylic acid (THCA-COOH) afforded norharman. These results suggest that food and naturally-occurring tetrahydro-beta-carboline alkaloids if accumulated in tissues, as reported elsewhere, might exhibit antioxidant activity.

Authors+Show Affiliations

therraiz@ifi.csic.esNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12420751

Citation

Herraiz, Tomas, and Juan Galisteo. "Tetrahydro-beta-carboline Alkaloids That Occur in Foods and Biological Systems Act as Radical Scavengers and Antioxidants in the ABTS Assay." Free Radical Research, vol. 36, no. 8, 2002, pp. 923-8.
Herraiz T, Galisteo J. Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay. Free Radic Res. 2002;36(8):923-8.
Herraiz, T., & Galisteo, J. (2002). Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay. Free Radical Research, 36(8), 923-8.
Herraiz T, Galisteo J. Tetrahydro-beta-carboline Alkaloids That Occur in Foods and Biological Systems Act as Radical Scavengers and Antioxidants in the ABTS Assay. Free Radic Res. 2002;36(8):923-8. PubMed PMID: 12420751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay. AU - Herraiz,Tomas, AU - Galisteo,Juan, PY - 2002/11/8/pubmed PY - 2003/4/18/medline PY - 2002/11/8/entrez SP - 923 EP - 8 JF - Free radical research JO - Free Radic Res VL - 36 IS - 8 N2 - Tetrahydro-beta-carboline alkaloids that occur in foods such as wine, seasonings, vinegar and fruit products juices, jams) acted as good radical scavengers (hydrogen- or electron donating) in the ABTS (2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay, and therefore, they could contribute to the beneficial antioxidant capacity attributed to foods. In contrast, the fully aromatic beta-carbolines norharman and harman did not show any radical scavenger activity in the same assay. During the reaction with ABTS.+ radical cation, tetrahydro-beta-carboline-3-carboxylic acid such as 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline-1,3-dicarboxylic acid (MTCA-COOH) were converted to harman, whereas 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (THCA) and 1,2,3,4-tetrahydro-beta-carboline-1,3-dicarboxylic acid (THCA-COOH) afforded norharman. These results suggest that food and naturally-occurring tetrahydro-beta-carboline alkaloids if accumulated in tissues, as reported elsewhere, might exhibit antioxidant activity. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/12420751/Tetrahydro_beta_carboline_alkaloids_that_occur_in_foods_and_biological_systems_act_as_radical_scavengers_and_antioxidants_in_the_ABTS_assay_ L2 - https://www.tandfonline.com/doi/full/10.1080/1071576021000005762 DB - PRIME DP - Unbound Medicine ER -