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Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata.
Insect Mol Biol. 2002 Dec; 11(6):611-8.IM

Abstract

Two defensin genes A and B were previously demonstrated to be up-regulated by blood feeding in the soft tick, Ornithodoros moubata [Nakajima et al. (2001) Two isoforms of a member of the arthropod defensin family from the soft tick, Ornithodoros moubata (Acari: Argasidae). Insect Biochem Mol Biol 31: 747-751]. In this study, two defensin isoforms C and D similar to defensins A and B were newly cloned. A total of four defensins have been identified in O. moubata. All four Ornithodoros defensins are coded as prepro-defensins. Ornithodoros defensin genes consist of four exons and three introns, an organization reported in mussel defensins but not insect defensins. Ornithodoros defensin C and D genes are predominantly expressed in the midgut and up-regulated in response to blood feeding. The mature peptide of the previously cloned Ornithodoros defensin A was purified from the midgut lumen, indicating defensin is secreted into the midgut. These findings confirm the involvement of Ornithodoros defensin in midgut immunity.

Authors+Show Affiliations

Institute of Agriculture and Forestry, University of Tsukuba, Tsukuba, Ibaraki, Japan. yamakawa@nias.affrc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12421419

Citation

Nakajima, Y, et al. "Antibacterial Peptide Defensin Is Involved in Midgut Immunity of the Soft Tick, Ornithodoros Moubata." Insect Molecular Biology, vol. 11, no. 6, 2002, pp. 611-8.
Nakajima Y, van der Goes van Naters-Yasui A, Taylor D, et al. Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata. Insect Mol Biol. 2002;11(6):611-8.
Nakajima, Y., van der Goes van Naters-Yasui, A., Taylor, D., & Yamakawa, M. (2002). Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata. Insect Molecular Biology, 11(6), 611-8.
Nakajima Y, et al. Antibacterial Peptide Defensin Is Involved in Midgut Immunity of the Soft Tick, Ornithodoros Moubata. Insect Mol Biol. 2002;11(6):611-8. PubMed PMID: 12421419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata. AU - Nakajima,Y, AU - van der Goes van Naters-Yasui,A, AU - Taylor,D, AU - Yamakawa,M, PY - 2002/11/8/pubmed PY - 2003/2/14/medline PY - 2002/11/8/entrez SP - 611 EP - 8 JF - Insect molecular biology JO - Insect Mol. Biol. VL - 11 IS - 6 N2 - Two defensin genes A and B were previously demonstrated to be up-regulated by blood feeding in the soft tick, Ornithodoros moubata [Nakajima et al. (2001) Two isoforms of a member of the arthropod defensin family from the soft tick, Ornithodoros moubata (Acari: Argasidae). Insect Biochem Mol Biol 31: 747-751]. In this study, two defensin isoforms C and D similar to defensins A and B were newly cloned. A total of four defensins have been identified in O. moubata. All four Ornithodoros defensins are coded as prepro-defensins. Ornithodoros defensin genes consist of four exons and three introns, an organization reported in mussel defensins but not insect defensins. Ornithodoros defensin C and D genes are predominantly expressed in the midgut and up-regulated in response to blood feeding. The mature peptide of the previously cloned Ornithodoros defensin A was purified from the midgut lumen, indicating defensin is secreted into the midgut. These findings confirm the involvement of Ornithodoros defensin in midgut immunity. SN - 0962-1075 UR - https://www.unboundmedicine.com/medline/citation/12421419/Antibacterial_peptide_defensin_is_involved_in_midgut_immunity_of_the_soft_tick_Ornithodoros_moubata_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0962-1075&date=2002&volume=11&issue=6&spage=611 DB - PRIME DP - Unbound Medicine ER -