Tags

Type your tag names separated by a space and hit enter

Effects of alpha-adrenoceptor agonists and antagonists on histamine-induced impairment of memory retention of passive avoidance learning in rats.
Eur J Pharmacol. 2002 Nov 15; 454(2-3):193-8.EJ

Abstract

The effect of alpha-adrenoceptor agents on the impairment induced by histamine was measured for memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injection was carried out in all the experiments. Histamine (5, 10 and 20 microg/rat) reduced, while a histamine H(1) receptor antagonist, chlorpheniramine (0.1, 1 and 10 microg/rat), increased memory retention. The histamine H(2) receptor antagonist, ranitidine (0.1, 1, 10 and 20 microg/rat), did not elicit any response in this respect. Different doses of chlorpheniramine but not ranitidine reversed the histamine-induced impairment of memory. Clonidine and prazosin decreased, but yohimbine and phenylephrine increased, memory retention. Yohimbine decreased the inhibitory response to histamine. Phenylephrine, clonidine and prazosin did not alter the histamine effect. It is concluded that a histamine-induced impairment of memory retention through histamine H(1) receptors and an alpha(2)-adrenoceptor mechanism may be involved in the histamine response.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran. zarinmr@ams.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12421647

Citation

Zarrindast, Mohammad-Reza, et al. "Effects of Alpha-adrenoceptor Agonists and Antagonists On Histamine-induced Impairment of Memory Retention of Passive Avoidance Learning in Rats." European Journal of Pharmacology, vol. 454, no. 2-3, 2002, pp. 193-8.
Zarrindast MR, Ahmadi R, Oryan S, et al. Effects of alpha-adrenoceptor agonists and antagonists on histamine-induced impairment of memory retention of passive avoidance learning in rats. Eur J Pharmacol. 2002;454(2-3):193-8.
Zarrindast, M. R., Ahmadi, R., Oryan, S., Parivar, K., & Haeri-Rohani, A. (2002). Effects of alpha-adrenoceptor agonists and antagonists on histamine-induced impairment of memory retention of passive avoidance learning in rats. European Journal of Pharmacology, 454(2-3), 193-8.
Zarrindast MR, et al. Effects of Alpha-adrenoceptor Agonists and Antagonists On Histamine-induced Impairment of Memory Retention of Passive Avoidance Learning in Rats. Eur J Pharmacol. 2002 Nov 15;454(2-3):193-8. PubMed PMID: 12421647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alpha-adrenoceptor agonists and antagonists on histamine-induced impairment of memory retention of passive avoidance learning in rats. AU - Zarrindast,Mohammad-Reza, AU - Ahmadi,Ramesh, AU - Oryan,Shahrbanoo, AU - Parivar,Kazem, AU - Haeri-Rohani,Ali, PY - 2002/11/8/pubmed PY - 2003/5/7/medline PY - 2002/11/8/entrez SP - 193 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 454 IS - 2-3 N2 - The effect of alpha-adrenoceptor agents on the impairment induced by histamine was measured for memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injection was carried out in all the experiments. Histamine (5, 10 and 20 microg/rat) reduced, while a histamine H(1) receptor antagonist, chlorpheniramine (0.1, 1 and 10 microg/rat), increased memory retention. The histamine H(2) receptor antagonist, ranitidine (0.1, 1, 10 and 20 microg/rat), did not elicit any response in this respect. Different doses of chlorpheniramine but not ranitidine reversed the histamine-induced impairment of memory. Clonidine and prazosin decreased, but yohimbine and phenylephrine increased, memory retention. Yohimbine decreased the inhibitory response to histamine. Phenylephrine, clonidine and prazosin did not alter the histamine effect. It is concluded that a histamine-induced impairment of memory retention through histamine H(1) receptors and an alpha(2)-adrenoceptor mechanism may be involved in the histamine response. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/12421647/Effects_of_alpha_adrenoceptor_agonists_and_antagonists_on_histamine_induced_impairment_of_memory_retention_of_passive_avoidance_learning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299902024974 DB - PRIME DP - Unbound Medicine ER -