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Effects of the amount and intensity of exercise on plasma lipoproteins.
N Engl J Med. 2002 Nov 07; 347(19):1483-92.NEJM

Abstract

BACKGROUND

Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins.

METHODS

A total of 111 sedentary, overweight men and women with mild-to-moderate dyslipidemia were randomly assigned to participate for six months in a control group or for approximately eight months in one of three exercise groups: high-amount-high-intensity exercise, the caloric equivalent of jogging 20 mi (32.0 km) per week at 65 to 80 percent of peak oxygen consumption; low-amount-high-intensity exercise, the equivalent of jogging 12 mi (19.2 km) per week at 65 to 80 percent of peak oxygen consumption; or low-amount-moderate-intensity exercise, the equivalent of walking 12 mi per week at 40 to 55 percent of peak oxygen consumption. Subjects were encouraged to maintain their base-line body weight. The 84 subjects who complied with these guidelines served as the basis for the main analysis. Detailed lipoprotein profiling was performed by nuclear magnetic resonance spectroscopy with verification by measurement of cholesterol in lipoprotein subfractions.

RESULTS

There was a beneficial effect of exercise on a variety of lipid and lipoprotein variables, seen most clearly with the high amount of high-intensity exercise. The high amount of exercise resulted in greater improvements than did the lower amounts of exercise (in 10 of 11 lipoprotein variables) and was always superior to the control condition (11 of 11 variables). Both lower-amount exercise groups always had better responses than the control group (22 of 22 comparisons).

CONCLUSIONS

The highest amount of weekly exercise, with minimal weight change, had widespread beneficial effects on the lipoprotein profile. The improvements were related to the amount of activity and not to the intensity of exercise or improvement in fitness.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. william.kraus@duke.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12421890

Citation

Kraus, William E., et al. "Effects of the Amount and Intensity of Exercise On Plasma Lipoproteins." The New England Journal of Medicine, vol. 347, no. 19, 2002, pp. 1483-92.
Kraus WE, Houmard JA, Duscha BD, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med. 2002;347(19):1483-92.
Kraus, W. E., Houmard, J. A., Duscha, B. D., Knetzger, K. J., Wharton, M. B., McCartney, J. S., Bales, C. W., Henes, S., Samsa, G. P., Otvos, J. D., Kulkarni, K. R., & Slentz, C. A. (2002). Effects of the amount and intensity of exercise on plasma lipoproteins. The New England Journal of Medicine, 347(19), 1483-92.
Kraus WE, et al. Effects of the Amount and Intensity of Exercise On Plasma Lipoproteins. N Engl J Med. 2002 Nov 7;347(19):1483-92. PubMed PMID: 12421890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the amount and intensity of exercise on plasma lipoproteins. AU - Kraus,William E, AU - Houmard,Joseph A, AU - Duscha,Brian D, AU - Knetzger,Kenneth J, AU - Wharton,Michelle B, AU - McCartney,Jennifer S, AU - Bales,Connie W, AU - Henes,Sarah, AU - Samsa,Gregory P, AU - Otvos,James D, AU - Kulkarni,Krishnaji R, AU - Slentz,Cris A, PY - 2002/11/8/pubmed PY - 2002/11/26/medline PY - 2002/11/8/entrez SP - 1483 EP - 92 JF - The New England journal of medicine JO - N Engl J Med VL - 347 IS - 19 N2 - BACKGROUND: Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins. METHODS: A total of 111 sedentary, overweight men and women with mild-to-moderate dyslipidemia were randomly assigned to participate for six months in a control group or for approximately eight months in one of three exercise groups: high-amount-high-intensity exercise, the caloric equivalent of jogging 20 mi (32.0 km) per week at 65 to 80 percent of peak oxygen consumption; low-amount-high-intensity exercise, the equivalent of jogging 12 mi (19.2 km) per week at 65 to 80 percent of peak oxygen consumption; or low-amount-moderate-intensity exercise, the equivalent of walking 12 mi per week at 40 to 55 percent of peak oxygen consumption. Subjects were encouraged to maintain their base-line body weight. The 84 subjects who complied with these guidelines served as the basis for the main analysis. Detailed lipoprotein profiling was performed by nuclear magnetic resonance spectroscopy with verification by measurement of cholesterol in lipoprotein subfractions. RESULTS: There was a beneficial effect of exercise on a variety of lipid and lipoprotein variables, seen most clearly with the high amount of high-intensity exercise. The high amount of exercise resulted in greater improvements than did the lower amounts of exercise (in 10 of 11 lipoprotein variables) and was always superior to the control condition (11 of 11 variables). Both lower-amount exercise groups always had better responses than the control group (22 of 22 comparisons). CONCLUSIONS: The highest amount of weekly exercise, with minimal weight change, had widespread beneficial effects on the lipoprotein profile. The improvements were related to the amount of activity and not to the intensity of exercise or improvement in fitness. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/12421890/Effects_of_the_amount_and_intensity_of_exercise_on_plasma_lipoproteins_ L2 - https://www.nejm.org/doi/10.1056/NEJMoa020194?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -