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Tomatoes, lycopene, and prostate cancer: progress and promise.
Exp Biol Med (Maywood). 2002 Nov; 227(10):869-80.EB

Abstract

Prostate cancer has emerged as a major public health problem in nations that have an affluent culture with an aging population. The search for etiologic risk factors and an emphasis on the development of chemopreventive agents has gained momentum over the last decade. Among the landmark epidemiologic findings during this period has been the association between the consumption of tomato products and a lower risk of prostate cancer. The traditional reductionist scientific approach has led many investigators to propose that lycopene, a carotenoid consumed largely from tomato products, may be the component responsible for lowering the risk of prostate cancer. Thus, many laboratory and clinical studies are now underway with the goal of assessing the ability of pure lycopene to serve as a chemopreventive agent for prostate and other malignancies. The focus on lycopene should continue, and an improved understanding of lycopene absorption, distribution, role in antioxidant reactions, and metabolism is critical in the quest to elucidate mechanisms whereby this compound could possibly reduce prostate cancer risk. In contrast to the pharmacologic approach with pure lycopene, many nutritional scientists direct their attention upon the diverse array of tomato products as a complex mixture of biologically active phytochemicals that together may have anti-prostate cancer benefits beyond those of any single constituent. These contrasting approaches will continue to be explored in clinical, laboratory and epidemiologic studies in the near future, providing hope that the next generation will benefit from this knowledge and experience a lower risk of prostate cancer.

Authors+Show Affiliations

Department of Food Science and Technology, Division of Hematology and Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12424328

Citation

Hadley, Craig W., et al. "Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise." Experimental Biology and Medicine (Maywood, N.J.), vol. 227, no. 10, 2002, pp. 869-80.
Hadley CW, Miller EC, Schwartz SJ, et al. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med (Maywood). 2002;227(10):869-80.
Hadley, C. W., Miller, E. C., Schwartz, S. J., & Clinton, S. K. (2002). Tomatoes, lycopene, and prostate cancer: progress and promise. Experimental Biology and Medicine (Maywood, N.J.), 227(10), 869-80.
Hadley CW, et al. Tomatoes, Lycopene, and Prostate Cancer: Progress and Promise. Exp Biol Med (Maywood). 2002;227(10):869-80. PubMed PMID: 12424328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tomatoes, lycopene, and prostate cancer: progress and promise. AU - Hadley,Craig W, AU - Miller,Elizabeth C, AU - Schwartz,Steven J, AU - Clinton,Steven K, PY - 2002/11/9/pubmed PY - 2002/12/20/medline PY - 2002/11/9/entrez SP - 869 EP - 80 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp. Biol. Med. (Maywood) VL - 227 IS - 10 N2 - Prostate cancer has emerged as a major public health problem in nations that have an affluent culture with an aging population. The search for etiologic risk factors and an emphasis on the development of chemopreventive agents has gained momentum over the last decade. Among the landmark epidemiologic findings during this period has been the association between the consumption of tomato products and a lower risk of prostate cancer. The traditional reductionist scientific approach has led many investigators to propose that lycopene, a carotenoid consumed largely from tomato products, may be the component responsible for lowering the risk of prostate cancer. Thus, many laboratory and clinical studies are now underway with the goal of assessing the ability of pure lycopene to serve as a chemopreventive agent for prostate and other malignancies. The focus on lycopene should continue, and an improved understanding of lycopene absorption, distribution, role in antioxidant reactions, and metabolism is critical in the quest to elucidate mechanisms whereby this compound could possibly reduce prostate cancer risk. In contrast to the pharmacologic approach with pure lycopene, many nutritional scientists direct their attention upon the diverse array of tomato products as a complex mixture of biologically active phytochemicals that together may have anti-prostate cancer benefits beyond those of any single constituent. These contrasting approaches will continue to be explored in clinical, laboratory and epidemiologic studies in the near future, providing hope that the next generation will benefit from this knowledge and experience a lower risk of prostate cancer. SN - 1535-3702 UR - https://www.unboundmedicine.com/medline/citation/12424328/Tomatoes_lycopene_and_prostate_cancer:_progress_and_promise_ L2 - http://journals.sagepub.com/doi/full/10.1177/153537020222701006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -