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Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder.
Psychopharmacology (Berl) 2002; 164(3):277-84P

Abstract

RATIONALE

Stimulant medications are the most commonly used treatments for attention deficit/hyperactivity disorder (ADHD) in North America and Australia, although it is still not entirely known how these medications work.

OBJECTIVES

This study aimed to investigate the effects of stimulant medications on the EEG of children with the Combined subtype of ADHD.

METHOD

An initial EEG was recorded during an eyes-closed resting condition and Fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. Theta/alpha and theta/beta ratios were also calculated. Subjects were placed on a 6-month trial of a stimulant and a second EEG was recorded at the end of the trial.

RESULTS

The ADHD group had significantly greater absolute delta and theta, less posterior absolute beta, more relative theta, and less relative alpha than the control group, which is typical of EEG studies of children with ADHD. The use of stimulant medications resulted in normalisation of the EEG, primarily evident in changes in the theta and beta bands.

CONCLUSIONS

These results suggest that stimulants act to increase cortical arousal in children with ADHD, normalising their brain activity.

Authors+Show Affiliations

Brain and Behaviour Research Institute, and Department of Psychology, University of Wollongong, Australia. adam_clarke@uow.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

12424551

Citation

Clarke, Adam R., et al. "Effects of Stimulant Medications On the EEG of Children With Attention-deficit/hyperactivity Disorder." Psychopharmacology, vol. 164, no. 3, 2002, pp. 277-84.
Clarke AR, Barry RJ, Bond D, et al. Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology (Berl). 2002;164(3):277-84.
Clarke, A. R., Barry, R. J., Bond, D., McCarthy, R., & Selikowitz, M. (2002). Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology, 164(3), pp. 277-84.
Clarke AR, et al. Effects of Stimulant Medications On the EEG of Children With Attention-deficit/hyperactivity Disorder. Psychopharmacology (Berl). 2002;164(3):277-84. PubMed PMID: 12424551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. AU - Clarke,Adam R, AU - Barry,Robert J, AU - Bond,Dominique, AU - McCarthy,Rory, AU - Selikowitz,Mark, Y1 - 2002/09/11/ PY - 2001/12/20/received PY - 2002/07/08/accepted PY - 2002/11/9/pubmed PY - 2003/4/10/medline PY - 2002/11/9/entrez SP - 277 EP - 84 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 164 IS - 3 N2 - RATIONALE: Stimulant medications are the most commonly used treatments for attention deficit/hyperactivity disorder (ADHD) in North America and Australia, although it is still not entirely known how these medications work. OBJECTIVES: This study aimed to investigate the effects of stimulant medications on the EEG of children with the Combined subtype of ADHD. METHOD: An initial EEG was recorded during an eyes-closed resting condition and Fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. Theta/alpha and theta/beta ratios were also calculated. Subjects were placed on a 6-month trial of a stimulant and a second EEG was recorded at the end of the trial. RESULTS: The ADHD group had significantly greater absolute delta and theta, less posterior absolute beta, more relative theta, and less relative alpha than the control group, which is typical of EEG studies of children with ADHD. The use of stimulant medications resulted in normalisation of the EEG, primarily evident in changes in the theta and beta bands. CONCLUSIONS: These results suggest that stimulants act to increase cortical arousal in children with ADHD, normalising their brain activity. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/12424551/Effects_of_stimulant_medications_on_the_EEG_of_children_with_attention_deficit/hyperactivity_disorder_ L2 - https://dx.doi.org/10.1007/s00213-002-1205-0 DB - PRIME DP - Unbound Medicine ER -