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Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome.
Am J Gastroenterol. 2002 Nov; 97(11):2738-43.AJ

Abstract

OBJECTIVES

Irritable bowel syndrome (IBS) and dyspepsia often overlap. Delayed gastric emptying has been reported in IBS patients, although conflicting results exist. Whether overlapping dyspepsia correlates with gastric emptying abnormalities in IBS patients has not been clarified. This study aimed to evaluate gastric emptying of solids and its relationship with dyspeptic symptoms in IBS patients.

METHODS

A total of 146 IBS outpatients seen in a referral center were evaluated for dyspeptic symptoms using a validated questionnaire. Gastric emptying of solids was evaluated scintigraphically in all patients and in 50 healthy controls.

RESULTS

Overlapping dyspepsia was diagnosed in 96 (66%) IBS patients. On average, gastric emptying rates were lower in IBS patients (mean +/- SEM, 33% +/- 1%/h) compared with controls (40% +/- 2%/h; p < 0.01). Specifically, gastric emptying was delayed in IBS patients with overlapping dyspepsia (31% +/- 1%/h; p < 0.01), whereas IBS patients without dyspeptic complaints showed gastric emptying rates (37% +/- 2%/h) that were similar to those of healthy controls (40% +/- 2%/h). Relevant postprandial fullness (OR = 4.7, 95% CI = 1.8-12.5) and relevant nausea (OR = 3.3, 95% CI 1.2-9.3) were independently associated with delayed gastric emptying.

CONCLUSIONS

IBS patients without overlapping dyspepsia have normal gastric emptying of solids. A significant association exists in IBS patients between delayed gastric emptying and overlapping relevant postprandial fullness and nausea.

Authors+Show Affiliations

Department of Internal Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12425541

Citation

Stanghellini, Vincenzo, et al. "Dyspeptic Symptoms and Gastric Emptying in the Irritable Bowel Syndrome." The American Journal of Gastroenterology, vol. 97, no. 11, 2002, pp. 2738-43.
Stanghellini V, Tosetti C, Barbara G, et al. Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. Am J Gastroenterol. 2002;97(11):2738-43.
Stanghellini, V., Tosetti, C., Barbara, G., De Giorgio, R., Cogliandro, L., Cogliandro, R., & Corinaldesi, R. (2002). Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. The American Journal of Gastroenterology, 97(11), 2738-43.
Stanghellini V, et al. Dyspeptic Symptoms and Gastric Emptying in the Irritable Bowel Syndrome. Am J Gastroenterol. 2002;97(11):2738-43. PubMed PMID: 12425541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. AU - Stanghellini,Vincenzo, AU - Tosetti,Cesare, AU - Barbara,Giovanni, AU - De Giorgio,Roberto, AU - Cogliandro,Laura, AU - Cogliandro,Rosanna, AU - Corinaldesi,Roberto, PY - 2002/11/12/pubmed PY - 2002/11/26/medline PY - 2002/11/12/entrez SP - 2738 EP - 43 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 97 IS - 11 N2 - OBJECTIVES: Irritable bowel syndrome (IBS) and dyspepsia often overlap. Delayed gastric emptying has been reported in IBS patients, although conflicting results exist. Whether overlapping dyspepsia correlates with gastric emptying abnormalities in IBS patients has not been clarified. This study aimed to evaluate gastric emptying of solids and its relationship with dyspeptic symptoms in IBS patients. METHODS: A total of 146 IBS outpatients seen in a referral center were evaluated for dyspeptic symptoms using a validated questionnaire. Gastric emptying of solids was evaluated scintigraphically in all patients and in 50 healthy controls. RESULTS: Overlapping dyspepsia was diagnosed in 96 (66%) IBS patients. On average, gastric emptying rates were lower in IBS patients (mean +/- SEM, 33% +/- 1%/h) compared with controls (40% +/- 2%/h; p < 0.01). Specifically, gastric emptying was delayed in IBS patients with overlapping dyspepsia (31% +/- 1%/h; p < 0.01), whereas IBS patients without dyspeptic complaints showed gastric emptying rates (37% +/- 2%/h) that were similar to those of healthy controls (40% +/- 2%/h). Relevant postprandial fullness (OR = 4.7, 95% CI = 1.8-12.5) and relevant nausea (OR = 3.3, 95% CI 1.2-9.3) were independently associated with delayed gastric emptying. CONCLUSIONS: IBS patients without overlapping dyspepsia have normal gastric emptying of solids. A significant association exists in IBS patients between delayed gastric emptying and overlapping relevant postprandial fullness and nausea. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12425541/Dyspeptic_symptoms_and_gastric_emptying_in_the_irritable_bowel_syndrome_ DB - PRIME DP - Unbound Medicine ER -