Tags

Type your tag names separated by a space and hit enter

Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study.

Abstract

OBJECTIVES

Several studies show that probiotics may prevent side effects during therapy against Helicobacter pylori (H. pylori). Other reports indicate competitive interaction between some probiotics and H. pylori. We compared efficacy of two different probiotics and one probiotic combination with placebo for preventing anti-H. pylori therapy-related side effects and for improving the eradication rate.

METHODS

A total of 85 H. pylori positive, asymptomatic patients were randomized in four groups to receive probiotic or placebo both during and for 7 days after a 1-wk triple therapy scheme (rabeprazole 20 mg b.id., clarithromycin 500 mg b.i.d., and tinidazole 500 mg b.i.d.). Group I (n = 21) received Lactobacillus GG; group II (n = 22), Saccharomyces boulardii; group III (n = 21), a combination of Lactobacillus spp. and biphidobacteria; and group IV (n = 21), placebo. Subjects filled in weekly symptom questionnaires for 4 wk. Blinded investigators collected and analyzed data. H. pylori status was rechecked after 5-7 wk.

RESULTS

Side effects occurred mainly during the eradication week. None of them caused therapy discontinuation. In all probiotic-supplemented groups, there was a significantly lower incidence of diarrhea and taste disturbance during the eradication week with respect to the placebo group. Overall assessment of tolerability was significantly better in the actively treated patients than in the placebo group. No differences in the incidence of side effects between the probiotic groups were observed. The H. pylori eradication rate was almost identical between the probiotic and placebo groups.

CONCLUSIONS

All the probiotics used were superior to placebo for side effect prevention, but were not associated with better compliance with antibiotic therapy. The effect of probiotic supplementation on side effects during anti-H. pylori regimens seemed to be independent of the probiotic species used.

Links

  • Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Università Cattolica del Sacro Cuore, Policlinico Gemelli, Roma, Italy.

    , , , , , , , ,

    Source

    MeSH

    Abdominal Pain
    Adult
    Anti-Bacterial Agents
    Constipation
    Diarrhea
    Double-Blind Method
    Feeding and Eating Disorders
    Female
    Flatulence
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Incidence
    Male
    Middle Aged
    Nausea
    Probiotics
    Taste Disorders
    Treatment Outcome
    Vomiting

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12425542

    Citation

    Cremonini, Filippo, et al. "Effect of Different Probiotic Preparations On Anti-helicobacter Pylori Therapy-related Side Effects: a Parallel Group, Triple Blind, Placebo-controlled Study." The American Journal of Gastroenterology, vol. 97, no. 11, 2002, pp. 2744-9.
    Cremonini F, Di Caro S, Covino M, et al. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 2002;97(11):2744-9.
    Cremonini, F., Di Caro, S., Covino, M., Armuzzi, A., Gabrielli, M., Santarelli, L., ... Gasbarrini, A. (2002). Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. The American Journal of Gastroenterology, 97(11), pp. 2744-9.
    Cremonini F, et al. Effect of Different Probiotic Preparations On Anti-helicobacter Pylori Therapy-related Side Effects: a Parallel Group, Triple Blind, Placebo-controlled Study. Am J Gastroenterol. 2002;97(11):2744-9. PubMed PMID: 12425542.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. AU - Cremonini,Filippo, AU - Di Caro,Simona, AU - Covino,Marcello, AU - Armuzzi,Alessandro, AU - Gabrielli,Maurizio, AU - Santarelli,Luca, AU - Nista,Enrico C, AU - Cammarota,Giovanni, AU - Gasbarrini,Giovanni, AU - Gasbarrini,Antonio, PY - 2002/11/12/pubmed PY - 2002/11/26/medline PY - 2002/11/12/entrez SP - 2744 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 97 IS - 11 N2 - OBJECTIVES: Several studies show that probiotics may prevent side effects during therapy against Helicobacter pylori (H. pylori). Other reports indicate competitive interaction between some probiotics and H. pylori. We compared efficacy of two different probiotics and one probiotic combination with placebo for preventing anti-H. pylori therapy-related side effects and for improving the eradication rate. METHODS: A total of 85 H. pylori positive, asymptomatic patients were randomized in four groups to receive probiotic or placebo both during and for 7 days after a 1-wk triple therapy scheme (rabeprazole 20 mg b.id., clarithromycin 500 mg b.i.d., and tinidazole 500 mg b.i.d.). Group I (n = 21) received Lactobacillus GG; group II (n = 22), Saccharomyces boulardii; group III (n = 21), a combination of Lactobacillus spp. and biphidobacteria; and group IV (n = 21), placebo. Subjects filled in weekly symptom questionnaires for 4 wk. Blinded investigators collected and analyzed data. H. pylori status was rechecked after 5-7 wk. RESULTS: Side effects occurred mainly during the eradication week. None of them caused therapy discontinuation. In all probiotic-supplemented groups, there was a significantly lower incidence of diarrhea and taste disturbance during the eradication week with respect to the placebo group. Overall assessment of tolerability was significantly better in the actively treated patients than in the placebo group. No differences in the incidence of side effects between the probiotic groups were observed. The H. pylori eradication rate was almost identical between the probiotic and placebo groups. CONCLUSIONS: All the probiotics used were superior to placebo for side effect prevention, but were not associated with better compliance with antibiotic therapy. The effect of probiotic supplementation on side effects during anti-H. pylori regimens seemed to be independent of the probiotic species used. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12425542/Effect_of_different_probiotic_preparations_on_anti_helicobacter_pylori_therapy_related_side_effects:_a_parallel_group_triple_blind_placebo_controlled_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2002&volume=97&issue=11&spage=2744 DB - PRIME DP - Unbound Medicine ER -