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Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project.
Am J Gastroenterol 2002; 97(11):2750-5AJ

Abstract

OBJECTIVE

The aim of this study was to examine whether smoking or consumption of alcohol or coffee is associated with active Helicobacter pylori (H. pylori) infection.

METHODS

This was a cross-sectional population study conducted as part of a randomized controlled trial of H. pylori infection eradication in southwest England. A total of 10,537 subjects, recruited from seven general practices, underwent 13C-urea breath testing for active infection with H. pylori and provided data on smoking, usual weekly consumption of alcohol, and daily intake of coffee.

RESULTS

Smoking or coffee consumption were not related to active H. pylori infection. Total alcohol consumption was associated with a small, but not statistically significant, decrease in the odds of infection. After adjustment for age, sex, ethnic status, childhood and adult social class, smoking, coffee consumption, and intake of alcoholic beverages other than wine, subjects drinking 3-6 units of wine/wk had an 11% lower risk of H. pylori infection compared with those who took no wine: OR = 0.89, 95% CI = 0.80-0.99. Higher wine consumption was associated with a further 6% reduction in the risk of infection: OR = 0.83, 95% CI = 0.64-1.07. Intake of 3-6 units of beer (but no greater intake) was associated with a similar reduction in the risk of infection when compared to no beer intake (OR = 0.83, 95% CI = 0.75-0.91).

CONCLUSIONS

This study indicates that modest consumption of wine and beer (approximately 7 units/wk) protects against H. pylori infection, presumably by facilitating eradication of the organism.

Authors+Show Affiliations

The Queen's University of Belfast, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12425543

Citation

Murray, Liam J., et al. "Inverse Relationship Between Alcohol Consumption and Active Helicobacter Pylori Infection: the Bristol Helicobacter Project." The American Journal of Gastroenterology, vol. 97, no. 11, 2002, pp. 2750-5.
Murray LJ, Lane AJ, Harvey IM, et al. Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project. Am J Gastroenterol. 2002;97(11):2750-5.
Murray, L. J., Lane, A. J., Harvey, I. M., Donovan, J. L., Nair, P., & Harvey, R. F. (2002). Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project. The American Journal of Gastroenterology, 97(11), pp. 2750-5.
Murray LJ, et al. Inverse Relationship Between Alcohol Consumption and Active Helicobacter Pylori Infection: the Bristol Helicobacter Project. Am J Gastroenterol. 2002;97(11):2750-5. PubMed PMID: 12425543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project. AU - Murray,Liam J, AU - Lane,Athene J, AU - Harvey,Ian M, AU - Donovan,Jenny L, AU - Nair,Prakash, AU - Harvey,Richard F, PY - 2002/11/12/pubmed PY - 2002/11/26/medline PY - 2002/11/12/entrez SP - 2750 EP - 5 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 97 IS - 11 N2 - OBJECTIVE: The aim of this study was to examine whether smoking or consumption of alcohol or coffee is associated with active Helicobacter pylori (H. pylori) infection. METHODS: This was a cross-sectional population study conducted as part of a randomized controlled trial of H. pylori infection eradication in southwest England. A total of 10,537 subjects, recruited from seven general practices, underwent 13C-urea breath testing for active infection with H. pylori and provided data on smoking, usual weekly consumption of alcohol, and daily intake of coffee. RESULTS: Smoking or coffee consumption were not related to active H. pylori infection. Total alcohol consumption was associated with a small, but not statistically significant, decrease in the odds of infection. After adjustment for age, sex, ethnic status, childhood and adult social class, smoking, coffee consumption, and intake of alcoholic beverages other than wine, subjects drinking 3-6 units of wine/wk had an 11% lower risk of H. pylori infection compared with those who took no wine: OR = 0.89, 95% CI = 0.80-0.99. Higher wine consumption was associated with a further 6% reduction in the risk of infection: OR = 0.83, 95% CI = 0.64-1.07. Intake of 3-6 units of beer (but no greater intake) was associated with a similar reduction in the risk of infection when compared to no beer intake (OR = 0.83, 95% CI = 0.75-0.91). CONCLUSIONS: This study indicates that modest consumption of wine and beer (approximately 7 units/wk) protects against H. pylori infection, presumably by facilitating eradication of the organism. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/12425543/Inverse_relationship_between_alcohol_consumption_and_active_Helicobacter_pylori_infection:_the_Bristol_Helicobacter_project_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2002&volume=97&issue=11&spage=2750 DB - PRIME DP - Unbound Medicine ER -