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Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels.
Br J Nutr. 2002 Nov; 88(5):479-88.BJ

Abstract

In a randomized, double-blind, placebo-controlled trial we evaluated the effect of dietary chocolates enriched with a wood-based phytosterol-phytostanol mixture, containing 18 % (w/w) sitostanol, compared with placebo dietary chocolates in seventy subjects with primary hypercholesterolaemia (total cholesterol levels below 8 mmol/l). For 4 weeks, participants consumed three servings of the phytosterol-enriched chocolate/d that provided 1.8 g unesterified phytosterols/d or a placebo chocolate in conjunction with a low-fat, low-cholesterol diet. Plasma total and LDL-cholesterol levels were statistically significantly reduced by 6.4 % (-0.44 mmol/l) and 10.3 % (-0.49 mmol/l), respectively, after 4 weeks of phytosterol-enriched-chocolate treatment. Plasma HDL-cholesterol and triacylglycerol levels were not affected. Consumption of phytosterol-enriched chocolates significantly increased plasma lathosterol concentration (+20.7 %), reflecting an increased endogenous cholesterol synthesis in response to phytosterol-induced decreased intestinal cholesterol absorption. Furthermore, the chocolates enriched with phytosterols significantly increased both plasma sitosterol (+95.8 %) and campesterol (+64.1 %) levels, compared with the placebo chocolate group. However, the absolute values of plasma sitosterol and campesterol remained within the normal range, that is, below 10 mg/l. The chocolates with phytosterols were palatable and induced no clinical or biochemical side effects. These findings indicate that dietary chocolate enriched with tall oil-derived phytosterols (1.8 g/d) is effective in lowering blood total and LDL-cholesterol levels in subjects with mild hypercholesterolaemia and thus may be helpful in reducing the risk of CHD in these individuals.

Authors+Show Affiliations

Department of General Internal Medicine, University Medical Centre Nijmegen, The Netherlands. J.deGraaf@aig.azn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12425728

Citation

De Graaf, Jacqueline, et al. "Consumption of Tall Oil-derived Phytosterols in a Chocolate Matrix Significantly Decreases Plasma Total and Low-density Lipoprotein-cholesterol Levels." The British Journal of Nutrition, vol. 88, no. 5, 2002, pp. 479-88.
De Graaf J, De Sauvage Nolting PR, Van Dam M, et al. Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. Br J Nutr. 2002;88(5):479-88.
De Graaf, J., De Sauvage Nolting, P. R., Van Dam, M., Belsey, E. M., Kastelein, J. J., Haydn Pritchard, P., & Stalenhoef, A. F. (2002). Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. The British Journal of Nutrition, 88(5), 479-88.
De Graaf J, et al. Consumption of Tall Oil-derived Phytosterols in a Chocolate Matrix Significantly Decreases Plasma Total and Low-density Lipoprotein-cholesterol Levels. Br J Nutr. 2002;88(5):479-88. PubMed PMID: 12425728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. AU - De Graaf,Jacqueline, AU - De Sauvage Nolting,Pernette R W, AU - Van Dam,Marjel, AU - Belsey,Elizabeth M, AU - Kastelein,John J P, AU - Haydn Pritchard,P, AU - Stalenhoef,Anton F H, PY - 2002/11/12/pubmed PY - 2002/12/17/medline PY - 2002/11/12/entrez SP - 479 EP - 88 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 88 IS - 5 N2 - In a randomized, double-blind, placebo-controlled trial we evaluated the effect of dietary chocolates enriched with a wood-based phytosterol-phytostanol mixture, containing 18 % (w/w) sitostanol, compared with placebo dietary chocolates in seventy subjects with primary hypercholesterolaemia (total cholesterol levels below 8 mmol/l). For 4 weeks, participants consumed three servings of the phytosterol-enriched chocolate/d that provided 1.8 g unesterified phytosterols/d or a placebo chocolate in conjunction with a low-fat, low-cholesterol diet. Plasma total and LDL-cholesterol levels were statistically significantly reduced by 6.4 % (-0.44 mmol/l) and 10.3 % (-0.49 mmol/l), respectively, after 4 weeks of phytosterol-enriched-chocolate treatment. Plasma HDL-cholesterol and triacylglycerol levels were not affected. Consumption of phytosterol-enriched chocolates significantly increased plasma lathosterol concentration (+20.7 %), reflecting an increased endogenous cholesterol synthesis in response to phytosterol-induced decreased intestinal cholesterol absorption. Furthermore, the chocolates enriched with phytosterols significantly increased both plasma sitosterol (+95.8 %) and campesterol (+64.1 %) levels, compared with the placebo chocolate group. However, the absolute values of plasma sitosterol and campesterol remained within the normal range, that is, below 10 mg/l. The chocolates with phytosterols were palatable and induced no clinical or biochemical side effects. These findings indicate that dietary chocolate enriched with tall oil-derived phytosterols (1.8 g/d) is effective in lowering blood total and LDL-cholesterol levels in subjects with mild hypercholesterolaemia and thus may be helpful in reducing the risk of CHD in these individuals. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12425728/Consumption_of_tall_oil_derived_phytosterols_in_a_chocolate_matrix_significantly_decreases_plasma_total_and_low_density_lipoprotein_cholesterol_levels_ L2 - https://www.cambridge.org/core/product/identifier/S0007114502002064/type/journal_article DB - PRIME DP - Unbound Medicine ER -