Tags

Type your tag names separated by a space and hit enter

The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study.
Arch Ophthalmol. 2002 Nov; 120(11):1551-8.AO

Abstract

OBJECTIVE

To examine the association between cataract and cataract surgery and the 10-year incidence of age-related maculopathy (ARM).

METHODS

A population-based cohort study of persons aged 43 to 86 years at baseline, living in Beaver Dam, Wis, of whom 3684 participated in a 5-year and 2764 in a 10-year follow-up. We used standardized protocols for physical examination, blood collection, health history, slitlamp and retroillumination photography of the lenses to determine the presence of cataract, and stereoscopic color fundus photography to determine the presence of ARM. We used the Kaplan-Meier (product-limit) survival approach and discrete linear logistic regression in analyses.

MAIN OUTCOME MEASURES

The risk ratios (RRs) of persons with cataract or cataract surgery at baseline.

RESULTS

While controlling for age, sex, systolic blood pressure, history of heavy drinking and smoking, and vitamin use, cataract at baseline was associated with incidence of early ARM (RR, 1.30; 95% confidence interval [CI], 1.04-1.63), soft indistinct drusen (RR, 1.38; 95% CI, 1.08-1.75), increased retinal pigment (RR, 1.38; 95% CI, 1.07-1.79), and progression of ARM (RR, 1.37; 95% CI, 1.06-1.77). We found no association with the incidence of late ARM. In contrast, cataract surgery before baseline was associated with incidence of late ARM (RR, 3.81; 95% CI, 1.89-7.69), increased retinal pigment (RR, 1.89; 95% CI, 1.18-3.03), retinal pigment epithelial depigmentation (RR, 1.95; 95% CI, 1.17-3.25), pure geographic atrophy (RR, 3.18; 95% CI, 1.33-7.60), exudative macular degeneration (RR, 4.31; 95% CI, 1.71-10.9), and progression of ARM (RR, 1.97; 95% CI, 1.29-3.02), but not with the incidence of early ARM.

CONCLUSIONS

These findings indicate an association of cataract with subsequent risk for early ARM. Cataract surgery increased the risk for late ARM.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 N Walnut St, 460 WARF, Madison, WI 53726-2397, USA. kleinr@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12427071

Citation

Klein, Ronald, et al. "The Association of Cataract and Cataract Surgery With the Long-term Incidence of Age-related Maculopathy: the Beaver Dam Eye Study." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 120, no. 11, 2002, pp. 1551-8.
Klein R, Klein BE, Wong TY, et al. The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. Arch Ophthalmol. 2002;120(11):1551-8.
Klein, R., Klein, B. E., Wong, T. Y., Tomany, S. C., & Cruickshanks, K. J. (2002). The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. Archives of Ophthalmology (Chicago, Ill. : 1960), 120(11), 1551-8.
Klein R, et al. The Association of Cataract and Cataract Surgery With the Long-term Incidence of Age-related Maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol. 2002;120(11):1551-8. PubMed PMID: 12427071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of cataract and cataract surgery with the long-term incidence of age-related maculopathy: the Beaver Dam eye study. AU - Klein,Ronald, AU - Klein,Barbara E K, AU - Wong,Tien Y, AU - Tomany,Sandra C, AU - Cruickshanks,Karen J, PY - 2002/11/13/pubmed PY - 2002/11/28/medline PY - 2002/11/13/entrez SP - 1551 EP - 8 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch Ophthalmol VL - 120 IS - 11 N2 - OBJECTIVE: To examine the association between cataract and cataract surgery and the 10-year incidence of age-related maculopathy (ARM). METHODS: A population-based cohort study of persons aged 43 to 86 years at baseline, living in Beaver Dam, Wis, of whom 3684 participated in a 5-year and 2764 in a 10-year follow-up. We used standardized protocols for physical examination, blood collection, health history, slitlamp and retroillumination photography of the lenses to determine the presence of cataract, and stereoscopic color fundus photography to determine the presence of ARM. We used the Kaplan-Meier (product-limit) survival approach and discrete linear logistic regression in analyses. MAIN OUTCOME MEASURES: The risk ratios (RRs) of persons with cataract or cataract surgery at baseline. RESULTS: While controlling for age, sex, systolic blood pressure, history of heavy drinking and smoking, and vitamin use, cataract at baseline was associated with incidence of early ARM (RR, 1.30; 95% confidence interval [CI], 1.04-1.63), soft indistinct drusen (RR, 1.38; 95% CI, 1.08-1.75), increased retinal pigment (RR, 1.38; 95% CI, 1.07-1.79), and progression of ARM (RR, 1.37; 95% CI, 1.06-1.77). We found no association with the incidence of late ARM. In contrast, cataract surgery before baseline was associated with incidence of late ARM (RR, 3.81; 95% CI, 1.89-7.69), increased retinal pigment (RR, 1.89; 95% CI, 1.18-3.03), retinal pigment epithelial depigmentation (RR, 1.95; 95% CI, 1.17-3.25), pure geographic atrophy (RR, 3.18; 95% CI, 1.33-7.60), exudative macular degeneration (RR, 4.31; 95% CI, 1.71-10.9), and progression of ARM (RR, 1.97; 95% CI, 1.29-3.02), but not with the incidence of early ARM. CONCLUSIONS: These findings indicate an association of cataract with subsequent risk for early ARM. Cataract surgery increased the risk for late ARM. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/12427071/The_association_of_cataract_and_cataract_surgery_with_the_long_term_incidence_of_age_related_maculopathy:_the_Beaver_Dam_eye_study_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/120/pg/1551 DB - PRIME DP - Unbound Medicine ER -