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Postsurgery enteral nutrition in head and neck cancer patients.
Eur J Clin Nutr 2002; 56(11):1126-9EJ

Abstract

OBJECTIVE

Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using an arginine-enriched diet, could improve nutritional variables as well as clinical outcomes.

DESIGN

Randomized clinical trial.

SETTING

Tertiary care.

SUBJECTS

A population of 47 patients with oral and laryngeal cancer were enrolled.

INTERVENTIONS

At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplemented with arginine and fiber (group I); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II).

RESULTS

No significant intergroup differences in the trend of the three plasma proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (17.4% group I and 8.3% group II; NS). During the 3 months after hospital discharge five patients died; no differences were detected between groups (13% group I and 8.3% group II; NS). The incidences postoperative infection complications were similar (nine patients) in both groups (21.7% group I and 16.7% group II; NS). Fistula were less frequent in enriched nutrition group (0% group I and 20.8% group II; P<0.05); wound infection was more frequent in group II, but without statistical difference (4.3% group I and 12.5% group II; NS). The length of postoperative stay was 22.8+/-11.8 days in the enriched group and 31.2+/-19.1 days in the control group (P=0.07).

CONCLUSIONS

In conclusion, enriched formula improves local wound complications in postoperative head and neck cancer patients. Our results suggest that these patients could benefit from an immunonutrient-enhanced enteral formula.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12428179

Citation

de Luis, D A., et al. "Postsurgery Enteral Nutrition in Head and Neck Cancer Patients." European Journal of Clinical Nutrition, vol. 56, no. 11, 2002, pp. 1126-9.
de Luis DA, Aller R, Izaola O, et al. Postsurgery enteral nutrition in head and neck cancer patients. Eur J Clin Nutr. 2002;56(11):1126-9.
de Luis, D. A., Aller, R., Izaola, O., Cuellar, L., & Terroba, M. C. (2002). Postsurgery enteral nutrition in head and neck cancer patients. European Journal of Clinical Nutrition, 56(11), pp. 1126-9.
de Luis DA, et al. Postsurgery Enteral Nutrition in Head and Neck Cancer Patients. Eur J Clin Nutr. 2002;56(11):1126-9. PubMed PMID: 12428179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postsurgery enteral nutrition in head and neck cancer patients. AU - de Luis,D A, AU - Aller,R, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, PY - 2001/07/01/received PY - 2002/11/13/pubmed PY - 2003/4/11/medline PY - 2002/11/13/entrez SP - 1126 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 11 N2 - OBJECTIVE: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using an arginine-enriched diet, could improve nutritional variables as well as clinical outcomes. DESIGN: Randomized clinical trial. SETTING: Tertiary care. SUBJECTS: A population of 47 patients with oral and laryngeal cancer were enrolled. INTERVENTIONS: At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplemented with arginine and fiber (group I); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II). RESULTS: No significant intergroup differences in the trend of the three plasma proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (17.4% group I and 8.3% group II; NS). During the 3 months after hospital discharge five patients died; no differences were detected between groups (13% group I and 8.3% group II; NS). The incidences postoperative infection complications were similar (nine patients) in both groups (21.7% group I and 16.7% group II; NS). Fistula were less frequent in enriched nutrition group (0% group I and 20.8% group II; P<0.05); wound infection was more frequent in group II, but without statistical difference (4.3% group I and 12.5% group II; NS). The length of postoperative stay was 22.8+/-11.8 days in the enriched group and 31.2+/-19.1 days in the control group (P=0.07). CONCLUSIONS: In conclusion, enriched formula improves local wound complications in postoperative head and neck cancer patients. Our results suggest that these patients could benefit from an immunonutrient-enhanced enteral formula. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12428179/Postsurgery_enteral_nutrition_in_head_and_neck_cancer_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601458 DB - PRIME DP - Unbound Medicine ER -