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Histaminergic modulation of stress-induced analgesia and cognitive dysfunction.
Methods Find Exp Clin Pharmacol. 2002 Sep; 24(7):413-9.MF

Abstract

Physiological stress is known to produce analgesia and memory disruption. A large body of evidence favors the nonopiate mediation of stress-induced analgesia. It is suggested that brain histamine mediates nonopiate analgesia and participates in learning and memory in rodents. Histamine is released during stress, although the nature of histaminergic involvement in stress response is not clearly defined. Therefore, we studied the effect of L-histidine and histamine-receptor antagonists on antinociception and impaired retention induced by immobilization stress. In the present study, immobilization stress produced a naloxone-resistant analgesia that was potentiated by L-histidine and antagonized by pretreatment with the histamine receptor antagonists chlorpheniramine and cimetidine. L-histidine attenuated the memory disruption induced by immobilization stress, which was significantly reversed by chlorpheniramine but not by cimetidine. Thus the involvement of the central histaminergic system, through histamine H1- and H2-receptors, may be speculated in analgesia and cognitive deficit induced by immobilization stress.

Authors+Show Affiliations

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12428429

Citation

Paul, V N., et al. "Histaminergic Modulation of Stress-induced Analgesia and Cognitive Dysfunction." Methods and Findings in Experimental and Clinical Pharmacology, vol. 24, no. 7, 2002, pp. 413-9.
Paul VN, Chopra K, Kulkarni SK. Histaminergic modulation of stress-induced analgesia and cognitive dysfunction. Methods Find Exp Clin Pharmacol. 2002;24(7):413-9.
Paul, V. N., Chopra, K., & Kulkarni, S. K. (2002). Histaminergic modulation of stress-induced analgesia and cognitive dysfunction. Methods and Findings in Experimental and Clinical Pharmacology, 24(7), 413-9.
Paul VN, Chopra K, Kulkarni SK. Histaminergic Modulation of Stress-induced Analgesia and Cognitive Dysfunction. Methods Find Exp Clin Pharmacol. 2002;24(7):413-9. PubMed PMID: 12428429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histaminergic modulation of stress-induced analgesia and cognitive dysfunction. AU - Paul,V N, AU - Chopra,K, AU - Kulkarni,S K, PY - 2002/11/14/pubmed PY - 2003/5/21/medline PY - 2002/11/14/entrez SP - 413 EP - 9 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 24 IS - 7 N2 - Physiological stress is known to produce analgesia and memory disruption. A large body of evidence favors the nonopiate mediation of stress-induced analgesia. It is suggested that brain histamine mediates nonopiate analgesia and participates in learning and memory in rodents. Histamine is released during stress, although the nature of histaminergic involvement in stress response is not clearly defined. Therefore, we studied the effect of L-histidine and histamine-receptor antagonists on antinociception and impaired retention induced by immobilization stress. In the present study, immobilization stress produced a naloxone-resistant analgesia that was potentiated by L-histidine and antagonized by pretreatment with the histamine receptor antagonists chlorpheniramine and cimetidine. L-histidine attenuated the memory disruption induced by immobilization stress, which was significantly reversed by chlorpheniramine but not by cimetidine. Thus the involvement of the central histaminergic system, through histamine H1- and H2-receptors, may be speculated in analgesia and cognitive deficit induced by immobilization stress. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/12428429/Histaminergic_modulation_of_stress_induced_analgesia_and_cognitive_dysfunction_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&p_RefId=696542 DB - PRIME DP - Unbound Medicine ER -