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Diuresis pattern, plasma vasopressin and blood pressure in healthy elderly persons with nocturia and nocturnal polyuria.
Neth J Med. 2002 Aug; 60(7):276-80.NJ

Abstract

BACKGROUND

Nocturia, a common symptom in the elderly, is often caused by increased urine production at night.

METHODS

The present study comprised 17 men and six women aged 68.1 +/- 4.7 (mean +/- SD) years with nocturia (> or = 2 nocturnal voids) and nocturnal polyuria (nocturnal urinary output of > or = 0.9 mL min(-1)). A physical examination, measurements of recumbent blood pressure after a 15-minute rest, plasma AVP assay at noon and midnight, and urine collection performed during a 24-hour period.

RESULTS

The daytime urine output was 1358 +/- 664 mL, and the nocturnal urine output 796 +/- 312 mL. The AVP level was lower at midnight than at noon in 17 persons, and higher at midnight in six persons. Blood pressure was 142.0 +/- 15.7/87.4 +/- 9.1 mmHg. Systolic (but not diastolic) blood pressure increased with decreasing nocturnal plasma AVP. Increasing nocturnal diuresis rate (r2= 0.26; p < 0.01) but not plasma AVP was associated with increasing systolic blood pressure.

CONCLUSION

In elderly persons with nocturia and nocturnal polyuria, the plasma AVP is low and does not rise nocturnally. The systolic blood pressure is increased with increasing diuresis but unaffected by plasma AVP.

Authors+Show Affiliations

Family Medicine Stockholm, Karolinska Institute, Research and Development Unit, Sweden. r.asplund@telia.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12430573

Citation

Asplund, R. "Diuresis Pattern, Plasma Vasopressin and Blood Pressure in Healthy Elderly Persons With Nocturia and Nocturnal Polyuria." The Netherlands Journal of Medicine, vol. 60, no. 7, 2002, pp. 276-80.
Asplund R. Diuresis pattern, plasma vasopressin and blood pressure in healthy elderly persons with nocturia and nocturnal polyuria. Neth J Med. 2002;60(7):276-80.
Asplund, R. (2002). Diuresis pattern, plasma vasopressin and blood pressure in healthy elderly persons with nocturia and nocturnal polyuria. The Netherlands Journal of Medicine, 60(7), 276-80.
Asplund R. Diuresis Pattern, Plasma Vasopressin and Blood Pressure in Healthy Elderly Persons With Nocturia and Nocturnal Polyuria. Neth J Med. 2002;60(7):276-80. PubMed PMID: 12430573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diuresis pattern, plasma vasopressin and blood pressure in healthy elderly persons with nocturia and nocturnal polyuria. A1 - Asplund,R, PY - 2002/11/15/pubmed PY - 2002/12/21/medline PY - 2002/11/15/entrez SP - 276 EP - 80 JF - The Netherlands journal of medicine JO - Neth J Med VL - 60 IS - 7 N2 - BACKGROUND: Nocturia, a common symptom in the elderly, is often caused by increased urine production at night. METHODS: The present study comprised 17 men and six women aged 68.1 +/- 4.7 (mean +/- SD) years with nocturia (> or = 2 nocturnal voids) and nocturnal polyuria (nocturnal urinary output of > or = 0.9 mL min(-1)). A physical examination, measurements of recumbent blood pressure after a 15-minute rest, plasma AVP assay at noon and midnight, and urine collection performed during a 24-hour period. RESULTS: The daytime urine output was 1358 +/- 664 mL, and the nocturnal urine output 796 +/- 312 mL. The AVP level was lower at midnight than at noon in 17 persons, and higher at midnight in six persons. Blood pressure was 142.0 +/- 15.7/87.4 +/- 9.1 mmHg. Systolic (but not diastolic) blood pressure increased with decreasing nocturnal plasma AVP. Increasing nocturnal diuresis rate (r2= 0.26; p < 0.01) but not plasma AVP was associated with increasing systolic blood pressure. CONCLUSION: In elderly persons with nocturia and nocturnal polyuria, the plasma AVP is low and does not rise nocturnally. The systolic blood pressure is increased with increasing diuresis but unaffected by plasma AVP. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/12430573/Diuresis_pattern_plasma_vasopressin_and_blood_pressure_in_healthy_elderly_persons_with_nocturia_and_nocturnal_polyuria_ L2 - http://www.njmonline.nl/njm/getarticle.php?v=60&amp;i=7&amp;p=276 DB - PRIME DP - Unbound Medicine ER -