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Fenfluramine and 5-hydroxytryptamine?. Part 1: Is fenfluramine or norfenfluramine involved in the decrease of brain 5-hydroxytryptamine.
Arzneimittelforschung. 1975 Nov; 25(11):1755-8.A

Abstract

Both fenfluramine and de-ethylated fenfluramine decrease the brain stores of 5-hydroxytryptamine (5-HT). As the fenfluramine metabolite is present in the brain of the rat after fenfluramine injection, it could be suggested that the depletion of brain 5-HT elicited by fenfluramine is mediated by its metabolite. Comparative studies on 5-HT lowering effects and drug brain levels, indicate a primary effect of fenfluramine, following by the rising involvement of the de-ethylated compound in the sustained effect.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

1243082

Citation

Duhault, J, et al. "Fenfluramine and 5-hydroxytryptamine?. Part 1: Is Fenfluramine or Norfenfluramine Involved in the Decrease of Brain 5-hydroxytryptamine." Arzneimittel-Forschung, vol. 25, no. 11, 1975, pp. 1755-8.
Duhault J, Malen C, Boulanger M, et al. Fenfluramine and 5-hydroxytryptamine?. Part 1: Is fenfluramine or norfenfluramine involved in the decrease of brain 5-hydroxytryptamine. Arzneimittelforschung. 1975;25(11):1755-8.
Duhault, J., Malen, C., Boulanger, M., Voisin, C., Beregi, L., & Schmitt, H. (1975). Fenfluramine and 5-hydroxytryptamine?. Part 1: Is fenfluramine or norfenfluramine involved in the decrease of brain 5-hydroxytryptamine. Arzneimittel-Forschung, 25(11), 1755-8.
Duhault J, et al. Fenfluramine and 5-hydroxytryptamine?. Part 1: Is Fenfluramine or Norfenfluramine Involved in the Decrease of Brain 5-hydroxytryptamine. Arzneimittelforschung. 1975;25(11):1755-8. PubMed PMID: 1243082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fenfluramine and 5-hydroxytryptamine?. Part 1: Is fenfluramine or norfenfluramine involved in the decrease of brain 5-hydroxytryptamine. AU - Duhault,J, AU - Malen,C, AU - Boulanger,M, AU - Voisin,C, AU - Beregi,L, AU - Schmitt,H, PY - 1975/11/1/pubmed PY - 1975/11/1/medline PY - 1975/11/1/entrez SP - 1755 EP - 8 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 25 IS - 11 N2 - Both fenfluramine and de-ethylated fenfluramine decrease the brain stores of 5-hydroxytryptamine (5-HT). As the fenfluramine metabolite is present in the brain of the rat after fenfluramine injection, it could be suggested that the depletion of brain 5-HT elicited by fenfluramine is mediated by its metabolite. Comparative studies on 5-HT lowering effects and drug brain levels, indicate a primary effect of fenfluramine, following by the rising involvement of the de-ethylated compound in the sustained effect. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/1243082/Fenfluramine_and_5_hydroxytryptamine__Part_1:_Is_fenfluramine_or_norfenfluramine_involved_in_the_decrease_of_brain_5_hydroxytryptamine_ L2 - https://antibodies.cancer.gov/detail/CPTC-HLA-B-1 DB - PRIME DP - Unbound Medicine ER -