Tags

Type your tag names separated by a space and hit enter

Blood rheology in deep venous thrombosis--relation to persistent and transient risk factors.
Thromb Res. 2002 Aug 15; 107(3-4):101-7.TR

Abstract

INTRODUCTION

The risk of recurrence in patients with symptomatic deep venous thrombosis (DVT) is higher in patients with persistent risk factors than in patients with transient risk factors. The purpose of this prospective study was to investigate the course of rheological variables in patients with DVT up to 1 year after the acute event in relation to risk factors.

PATIENTS AND METHODS

In 37 patients with proven DVT plasma fibrinogen, plasma viscosity, red cell aggregation, whole blood viscosity, hematocrit and platelet aggregation were studied in the acute phase, at 6 weeks and at 12 months.

RESULTS

In the acute phase, patients had higher fibrinogen (medians and ranges; 450 [270-611] vs. 247 [170-340] mg/dl, p < 0.01), plasma viscosity (1.67 [1.48-1.96] vs. 1.60 [1.50-1.70] mPa s, p < 0.01), red cell aggregation (9.76 [5.87-12.66] vs. 5.66 [3.67-8.46] arbitrary units; p < 0.01) and whole blood viscosity (5.78 [5.61-5.87] vs. 5.59 [5.27-5.9] mPa s, p < 0.01), but lower hematocrit (40 [32-46] vs. 45 [38-50]%, p < 0.01) and platelet aggregation (by epinephrine: 41 [13-85] vs. 79 [29-91]%, (p < 0.01) than controls. During the 1-year follow-up, fibrinogen, plasma viscosity, red cell aggregation and whole blood viscosity constantly decreased, whereas hematocrit and platelet aggregation increased in the total of patients (all p < 0.01). Subgroup analysis according to risk factors showed that at 12 months patients with persistent risk factors (N = 21) had higher plasma fibrinogen (357 [235-450] vs. 247 [214-335] mg/dl, p < 0.01), plasma viscosity (1.65 [1.50-1.80] vs. 1.59 [1.42-1.77] mPa s, p < 0.05) and red cell aggregation (7.82 [6.0-11.3] vs. 6.3 [5.2-7.1] arb. units, p < 0.01) than patients with transient risk factors (N = 16). Compared with controls, these variables were increased in patients with persistent risk factors (all p < 0.01), but not in patients with transient risk factors (all n.s.).

CONCLUSION

In patients with persistent risk factors rheological changes are still present 1 year after acute DVT, whereas in patients with transient risk factors blood rheology returns to normal. Further studies are needed to clarify whether blood rheology might be helpful to identify patients at high risk of recurrence.

Authors+Show Affiliations

Division of Angiology, Department of Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12431474

Citation

Alt, Elisabeth, et al. "Blood Rheology in Deep Venous Thrombosis--relation to Persistent and Transient Risk Factors." Thrombosis Research, vol. 107, no. 3-4, 2002, pp. 101-7.
Alt E, Banyai S, Banyai M, et al. Blood rheology in deep venous thrombosis--relation to persistent and transient risk factors. Thromb Res. 2002;107(3-4):101-7.
Alt, E., Banyai, S., Banyai, M., & Koppensteiner, R. (2002). Blood rheology in deep venous thrombosis--relation to persistent and transient risk factors. Thrombosis Research, 107(3-4), 101-7.
Alt E, et al. Blood Rheology in Deep Venous Thrombosis--relation to Persistent and Transient Risk Factors. Thromb Res. 2002 Aug 15;107(3-4):101-7. PubMed PMID: 12431474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood rheology in deep venous thrombosis--relation to persistent and transient risk factors. AU - Alt,Elisabeth, AU - Banyai,Susanne, AU - Banyai,Martin, AU - Koppensteiner,Renate, PY - 2002/11/15/pubmed PY - 2003/10/11/medline PY - 2002/11/15/entrez SP - 101 EP - 7 JF - Thrombosis research JO - Thromb Res VL - 107 IS - 3-4 N2 - INTRODUCTION: The risk of recurrence in patients with symptomatic deep venous thrombosis (DVT) is higher in patients with persistent risk factors than in patients with transient risk factors. The purpose of this prospective study was to investigate the course of rheological variables in patients with DVT up to 1 year after the acute event in relation to risk factors. PATIENTS AND METHODS: In 37 patients with proven DVT plasma fibrinogen, plasma viscosity, red cell aggregation, whole blood viscosity, hematocrit and platelet aggregation were studied in the acute phase, at 6 weeks and at 12 months. RESULTS: In the acute phase, patients had higher fibrinogen (medians and ranges; 450 [270-611] vs. 247 [170-340] mg/dl, p < 0.01), plasma viscosity (1.67 [1.48-1.96] vs. 1.60 [1.50-1.70] mPa s, p < 0.01), red cell aggregation (9.76 [5.87-12.66] vs. 5.66 [3.67-8.46] arbitrary units; p < 0.01) and whole blood viscosity (5.78 [5.61-5.87] vs. 5.59 [5.27-5.9] mPa s, p < 0.01), but lower hematocrit (40 [32-46] vs. 45 [38-50]%, p < 0.01) and platelet aggregation (by epinephrine: 41 [13-85] vs. 79 [29-91]%, (p < 0.01) than controls. During the 1-year follow-up, fibrinogen, plasma viscosity, red cell aggregation and whole blood viscosity constantly decreased, whereas hematocrit and platelet aggregation increased in the total of patients (all p < 0.01). Subgroup analysis according to risk factors showed that at 12 months patients with persistent risk factors (N = 21) had higher plasma fibrinogen (357 [235-450] vs. 247 [214-335] mg/dl, p < 0.01), plasma viscosity (1.65 [1.50-1.80] vs. 1.59 [1.42-1.77] mPa s, p < 0.05) and red cell aggregation (7.82 [6.0-11.3] vs. 6.3 [5.2-7.1] arb. units, p < 0.01) than patients with transient risk factors (N = 16). Compared with controls, these variables were increased in patients with persistent risk factors (all p < 0.01), but not in patients with transient risk factors (all n.s.). CONCLUSION: In patients with persistent risk factors rheological changes are still present 1 year after acute DVT, whereas in patients with transient risk factors blood rheology returns to normal. Further studies are needed to clarify whether blood rheology might be helpful to identify patients at high risk of recurrence. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/12431474/Blood_rheology_in_deep_venous_thrombosis__relation_to_persistent_and_transient_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S004938480200302X DB - PRIME DP - Unbound Medicine ER -