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Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects.
Neuropsychopharmacology 2002; 27(5):843-51N

Abstract

Because serotonin is involved in the diachronic regulation of sleep, we tested the effect of a midmorning rapid deficiency in the serotonin precursor tryptophan on the next night's sleep. After a 48-h low-protein diet, 17 healthy volunteers received either a tryptophan-free mixture of amino acids or a placebo at 10:30 A.M., in a randomized double-blind cross-over design, resulting in a 77% decrease and 41% decrease of serum tryptophan at 3:30 P.M. and 9:30 P.M., respectively. Urinary sulfatoxy-melatonin excretion and mood were unaffected by the rapid tryptophan depletion (RTD), but rapid eye movement (REM) sleep latency increased by 21 min (from 91.5 +/- 4.5 min to 112.2 +/- 6.9 min), sleep fragmentation 58%, and REM density of the first REM sleep period doubled. The results show that midmorning RTD delays REM sleep latency during following night-time sleep, whereas evening RTD shortens REM sleep latency in previous studies, and suggest that the serotonin control of REM sleep latency is upregulated.

Authors+Show Affiliations

AP-HP, Centre d'Investigation Clinique, Fédération des Pathologies du Sommeil et UPRES EA 2397, Paris, France. isabelle.arnulf@psl.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12431858

Citation

Arnulf, Isabelle, et al. "Mid-morning Tryptophan Depletion Delays REM Sleep Onset in Healthy Subjects." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 27, no. 5, 2002, pp. 843-51.
Arnulf I, Quintin P, Alvarez JC, et al. Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects. Neuropsychopharmacology. 2002;27(5):843-51.
Arnulf, I., Quintin, P., Alvarez, J. C., Vigil, L., Touitou, Y., Lèbre, A. S., ... Leboyer, M. (2002). Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 27(5), pp. 843-51.
Arnulf I, et al. Mid-morning Tryptophan Depletion Delays REM Sleep Onset in Healthy Subjects. Neuropsychopharmacology. 2002;27(5):843-51. PubMed PMID: 12431858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mid-morning tryptophan depletion delays REM sleep onset in healthy subjects. AU - Arnulf,Isabelle, AU - Quintin,Philippe, AU - Alvarez,Jean Claude, AU - Vigil,Laurence, AU - Touitou,Yvan, AU - Lèbre,Anne Sophie, AU - Bellenger,Agnès, AU - Varoquaux,Odile, AU - Derenne,Jean Philippe, AU - Allilaire,Jean François, AU - Benkelfat,Chawki, AU - Leboyer,Marion, PY - 2002/11/15/pubmed PY - 2002/12/27/medline PY - 2002/11/15/entrez SP - 843 EP - 51 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 27 IS - 5 N2 - Because serotonin is involved in the diachronic regulation of sleep, we tested the effect of a midmorning rapid deficiency in the serotonin precursor tryptophan on the next night's sleep. After a 48-h low-protein diet, 17 healthy volunteers received either a tryptophan-free mixture of amino acids or a placebo at 10:30 A.M., in a randomized double-blind cross-over design, resulting in a 77% decrease and 41% decrease of serum tryptophan at 3:30 P.M. and 9:30 P.M., respectively. Urinary sulfatoxy-melatonin excretion and mood were unaffected by the rapid tryptophan depletion (RTD), but rapid eye movement (REM) sleep latency increased by 21 min (from 91.5 +/- 4.5 min to 112.2 +/- 6.9 min), sleep fragmentation 58%, and REM density of the first REM sleep period doubled. The results show that midmorning RTD delays REM sleep latency during following night-time sleep, whereas evening RTD shortens REM sleep latency in previous studies, and suggest that the serotonin control of REM sleep latency is upregulated. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/12431858/Mid_morning_tryptophan_depletion_delays_REM_sleep_onset_in_healthy_subjects_ L2 - http://dx.doi.org/10.1016/S0893-133X(02)00358-5 DB - PRIME DP - Unbound Medicine ER -