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Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions.
Bull Exp Biol Med. 2002 Feb; 133(2):133-5.BE

Abstract

Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mice by the half-life of plasma leu-enkephalin. Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice. Our results suggest that anxiolytic activity of Selank is associated with inhibition of enkephalin-degrading enzymes.

Authors+Show Affiliations

Sokolov OY
Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow. sokolov@rcmh.msk.ru
Meshavkin VK
No affiliation info available
Kost NV
No affiliation info available
Zozulya AA
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsEnkephalin, LeucineHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLMotor ActivityNeprilysinOligopeptidesPhenotypeStress, Physiological

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12432865

Citation

Sokolov, O Yu, et al. "Effects of Selank On Behavioral Reactions and Activities of Plasma Enkephalin-degrading Enzymes in Mice With Different Phenotypes of Emotional and Stress Reactions." Bulletin of Experimental Biology and Medicine, vol. 133, no. 2, 2002, pp. 133-5.
Sokolov OY, Meshavkin VK, Kost NV, et al. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull Exp Biol Med. 2002;133(2):133-5.
Sokolov, O. Y., Meshavkin, V. K., Kost, N. V., & Zozulya, A. A. (2002). Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bulletin of Experimental Biology and Medicine, 133(2), 133-5.
Sokolov OY, et al. Effects of Selank On Behavioral Reactions and Activities of Plasma Enkephalin-degrading Enzymes in Mice With Different Phenotypes of Emotional and Stress Reactions. Bull Exp Biol Med. 2002;133(2):133-5. PubMed PMID: 12432865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. AU - Sokolov,O Yu, AU - Meshavkin,V K, AU - Kost,N V, AU - Zozulya,A A, PY - 2002/11/16/pubmed PY - 2003/7/29/medline PY - 2002/11/16/entrez SP - 133 EP - 5 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 133 IS - 2 N2 - Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mice by the half-life of plasma leu-enkephalin. Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice. Our results suggest that anxiolytic activity of Selank is associated with inhibition of enkephalin-degrading enzymes. SN - 0007-4888 UR - https://www.unboundmedicine.com/medline/citation/12432865/Effects_of_Selank_on_behavioral_reactions_and_activities_of_plasma_enkephalin_degrading_enzymes_in_mice_with_different_phenotypes_of_emotional_and_stress_reactions_ DB - PRIME DP - Unbound Medicine ER -