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Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment.
Aviat Space Environ Med. 2002 Nov; 73(11):1079-88.AS

Abstract

BACKGROUND

Previous studies have revealed that modafinil elevates resting core temperature during periods of sustained wakefulness. The purpose of this study was to examine the effects of modafinil on core temperature during rest and exercise throughout 40 h of sustained wakefulness in a warm environment.

METHODS

Ten males performed a drug session (three 100 mg doses per day) and a placebo session that involved a control day, 40 h of sustained wakefulness, and a recovery sleep. For 38 h of the sustained wakefulness, subjects were exposed to 30 degrees C with 50% relative humidity. During the afternoon of both days of wakefulness and during the early morning of the second day, subjects performed 2 h of exercise at 60% VO2max while exposed to the warm environment.

RESULTS

The data revealed that rectal temperature (Tre) was elevated at rest 0.15-0.2 degrees C following modafinil ingestion throughout the period of sustained wakefulness. This increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day. During exercise, an inconsistent effect of the drug on Tre was observed throughout the 38-h period. On the first afternoon, the impact of modafinil on Tre was no longer evident after 20 min of exercise. In contrast, during the early morning and afternoon of the second day, the effects of the drug on Tre at rest remained during exercise. For seven subjects who had Tre data for 80 min during all exercise periods, Tre during the placebo session was 38.9, 38.4, and 38.7 degrees C after 80 min of exercise for periods one, two and three, respectively, whereas the corresponding values during the modafinil session were 38.8, 38.7, and 38.9 degrees C.

CONCLUSION

With a greater cumulative dose of the drug, Tre remained elevated throughout the exercise period to an extent similar to the increase observed under resting conditions when compared with the placebo condition.

Authors+Show Affiliations

Defence and Civil Institute of Environmental Medicine, Environmental and Applied Ergonomics Section, Toronto, ON, Canada. tmclella@drdc-rddc.gc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12433231

Citation

McLellan, Tom M., et al. "Effect of Modafinil On Core Temperature During Sustained Wakefulness and Exercise in a Warm Environment." Aviation, Space, and Environmental Medicine, vol. 73, no. 11, 2002, pp. 1079-88.
McLellan TM, Ducharme MB, Canini F, et al. Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment. Aviat Space Environ Med. 2002;73(11):1079-88.
McLellan, T. M., Ducharme, M. B., Canini, F., Moroz, D., Bell, D. G., Baranski, J. V., Gil, V., Buguet, A., & Radomski, M. W. (2002). Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment. Aviation, Space, and Environmental Medicine, 73(11), 1079-88.
McLellan TM, et al. Effect of Modafinil On Core Temperature During Sustained Wakefulness and Exercise in a Warm Environment. Aviat Space Environ Med. 2002;73(11):1079-88. PubMed PMID: 12433231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of modafinil on core temperature during sustained wakefulness and exercise in a warm environment. AU - McLellan,Tom M, AU - Ducharme,Michel B, AU - Canini,Frédéric, AU - Moroz,Dianne, AU - Bell,Doug G, AU - Baranski,Joseph V, AU - Gil,Valerie, AU - Buguet,Alain, AU - Radomski,Manny W, PY - 2002/11/16/pubmed PY - 2003/2/22/medline PY - 2002/11/16/entrez SP - 1079 EP - 88 JF - Aviation, space, and environmental medicine JO - Aviat Space Environ Med VL - 73 IS - 11 N2 - BACKGROUND: Previous studies have revealed that modafinil elevates resting core temperature during periods of sustained wakefulness. The purpose of this study was to examine the effects of modafinil on core temperature during rest and exercise throughout 40 h of sustained wakefulness in a warm environment. METHODS: Ten males performed a drug session (three 100 mg doses per day) and a placebo session that involved a control day, 40 h of sustained wakefulness, and a recovery sleep. For 38 h of the sustained wakefulness, subjects were exposed to 30 degrees C with 50% relative humidity. During the afternoon of both days of wakefulness and during the early morning of the second day, subjects performed 2 h of exercise at 60% VO2max while exposed to the warm environment. RESULTS: The data revealed that rectal temperature (Tre) was elevated at rest 0.15-0.2 degrees C following modafinil ingestion throughout the period of sustained wakefulness. This increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day. During exercise, an inconsistent effect of the drug on Tre was observed throughout the 38-h period. On the first afternoon, the impact of modafinil on Tre was no longer evident after 20 min of exercise. In contrast, during the early morning and afternoon of the second day, the effects of the drug on Tre at rest remained during exercise. For seven subjects who had Tre data for 80 min during all exercise periods, Tre during the placebo session was 38.9, 38.4, and 38.7 degrees C after 80 min of exercise for periods one, two and three, respectively, whereas the corresponding values during the modafinil session were 38.8, 38.7, and 38.9 degrees C. CONCLUSION: With a greater cumulative dose of the drug, Tre remained elevated throughout the exercise period to an extent similar to the increase observed under resting conditions when compared with the placebo condition. SN - 0095-6562 UR - https://www.unboundmedicine.com/medline/citation/12433231/Effect_of_modafinil_on_core_temperature_during_sustained_wakefulness_and_exercise_in_a_warm_environment_ L2 - https://medlineplus.gov/exerciseandphysicalfitness.html DB - PRIME DP - Unbound Medicine ER -