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Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
Int J Pharm. 2002 Dec 05; 249(1-2):165-74.IJ

Abstract

Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 microm and encapsulation efficiencies of drug were more than 90%. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing MW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery system to control the release of drug.

Authors+Show Affiliations

Graduate School of Biotechnology, Korea University, Seoul 136-701, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12433445

Citation

Ko, J A., et al. "Preparation and Characterization of Chitosan Microparticles Intended for Controlled Drug Delivery." International Journal of Pharmaceutics, vol. 249, no. 1-2, 2002, pp. 165-74.
Ko JA, Park HJ, Hwang SJ, et al. Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm. 2002;249(1-2):165-74.
Ko, J. A., Park, H. J., Hwang, S. J., Park, J. B., & Lee, J. S. (2002). Preparation and characterization of chitosan microparticles intended for controlled drug delivery. International Journal of Pharmaceutics, 249(1-2), 165-74.
Ko JA, et al. Preparation and Characterization of Chitosan Microparticles Intended for Controlled Drug Delivery. Int J Pharm. 2002 Dec 5;249(1-2):165-74. PubMed PMID: 12433445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of chitosan microparticles intended for controlled drug delivery. AU - Ko,J A, AU - Park,H J, AU - Hwang,S J, AU - Park,J B, AU - Lee,J S, PY - 2002/11/16/pubmed PY - 2003/5/21/medline PY - 2002/11/16/entrez SP - 165 EP - 74 JF - International journal of pharmaceutics JO - Int J Pharm VL - 249 IS - 1-2 N2 - Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 microm and encapsulation efficiencies of drug were more than 90%. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing MW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery system to control the release of drug. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/12433445/Preparation_and_characterization_of_chitosan_microparticles_intended_for_controlled_drug_delivery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378517302004878 DB - PRIME DP - Unbound Medicine ER -