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Cost-effectiveness analysis of screening for osteoporosis in postmenopausal Japanese women.
J Bone Miner Metab. 2002; 20(6):350-7.JB

Abstract

Osteoporosis-related hip fracture is an important cause of mortality and morbidity in older people. In an aging society such as Japan's, prevention and treatment of osteoporosis is of paramount importance in reducing the risk of hip fracture. To determine the efficiency of screening by dual-energy X-ray absorptiometry for reducing the incidence of hip fracture, a cost-effectiveness analysis was conducted using a state-transition model. We compared the following four strategies in a hypothetical cohort of postmenopausal Japanese women: (1) no intervention; (2) hormone replacement therapy (HRT) for patients with osteoporosis after screening; (3) HRT for patients with osteopenia and osteoporosis after screening; and (4) universal HRT. Epidemiological and economic data were collected from published articles. HRT for patients with osteoporosis after screening was the most cost-effective strategy, with the marginal cost-effectiveness being 5.36 million yen/quality-adjusted life year (QALY). The ratios for other strategies exceeded 10 million yen/QALY. Sensitivity analyses showed that the drug effect and treatment cost of HRT had a significant influence on the results. Screening postmenopausal Japanese women and treating patients with osteoporosis may be an acceptable strategy, but its cost-effectiveness ratio seems only fair at present.

Authors+Show Affiliations

Department of General Medicine and Clinical Epidemiology, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12434163

Citation

Nagata-Kobayashi, Shizuko, et al. "Cost-effectiveness Analysis of Screening for Osteoporosis in Postmenopausal Japanese Women." Journal of Bone and Mineral Metabolism, vol. 20, no. 6, 2002, pp. 350-7.
Nagata-Kobayashi S, Shimbo T, Fukui T. Cost-effectiveness analysis of screening for osteoporosis in postmenopausal Japanese women. J Bone Miner Metab. 2002;20(6):350-7.
Nagata-Kobayashi, S., Shimbo, T., & Fukui, T. (2002). Cost-effectiveness analysis of screening for osteoporosis in postmenopausal Japanese women. Journal of Bone and Mineral Metabolism, 20(6), 350-7.
Nagata-Kobayashi S, Shimbo T, Fukui T. Cost-effectiveness Analysis of Screening for Osteoporosis in Postmenopausal Japanese Women. J Bone Miner Metab. 2002;20(6):350-7. PubMed PMID: 12434163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost-effectiveness analysis of screening for osteoporosis in postmenopausal Japanese women. AU - Nagata-Kobayashi,Shizuko, AU - Shimbo,Takuro, AU - Fukui,Tsuguya, PY - 2002/11/16/pubmed PY - 2003/12/12/medline PY - 2002/11/16/entrez SP - 350 EP - 7 JF - Journal of bone and mineral metabolism JO - J Bone Miner Metab VL - 20 IS - 6 N2 - Osteoporosis-related hip fracture is an important cause of mortality and morbidity in older people. In an aging society such as Japan's, prevention and treatment of osteoporosis is of paramount importance in reducing the risk of hip fracture. To determine the efficiency of screening by dual-energy X-ray absorptiometry for reducing the incidence of hip fracture, a cost-effectiveness analysis was conducted using a state-transition model. We compared the following four strategies in a hypothetical cohort of postmenopausal Japanese women: (1) no intervention; (2) hormone replacement therapy (HRT) for patients with osteoporosis after screening; (3) HRT for patients with osteopenia and osteoporosis after screening; and (4) universal HRT. Epidemiological and economic data were collected from published articles. HRT for patients with osteoporosis after screening was the most cost-effective strategy, with the marginal cost-effectiveness being 5.36 million yen/quality-adjusted life year (QALY). The ratios for other strategies exceeded 10 million yen/QALY. Sensitivity analyses showed that the drug effect and treatment cost of HRT had a significant influence on the results. Screening postmenopausal Japanese women and treating patients with osteoporosis may be an acceptable strategy, but its cost-effectiveness ratio seems only fair at present. SN - 0914-8779 UR - https://www.unboundmedicine.com/medline/citation/12434163/Cost_effectiveness_analysis_of_screening_for_osteoporosis_in_postmenopausal_Japanese_women_ L2 - https://dx.doi.org/10.1007/s007740200051 DB - PRIME DP - Unbound Medicine ER -