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[The effect of simulated weightlessness on the function of spleen lymphocytes and the expression of c-fos proto-oncogene in tail-suspended mice].
Space Med Med Eng (Beijing). 1999 Dec; 12(6):423-5.SM

Abstract

Objective.

To investigate the effect of simulated weightlessness on proliferation of spleen lymphocyte, production of interleukin-2 and expression of c-fos proto-oncogene in mice.

Method.

Mice were tail-suspended for 7 or 14 days to simulate the effect of weightlessness; proliferation of lymphocyte was measured by MTT method, production of IL-2 was determined by biological activity and expression of c-fos proto-oncogene was determined by dot blotting. Result. As compared with the control, the proliferation of spleen lymphocyte and the production of IL-2 were significantly decreased in 14 d suspended group, but the expression of c-fos proto-oncogene [correction of oncogen] was increased in both 7 d and 14 d suspended groups.

Conclusion.

This result suggested that simulated weightlessness could interfere with the genes regulating the lymphocyte.

Authors+Show Affiliations

Institute of Space Medico-Engineering, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12434808

Citation

Zhang, H, et al. "[The Effect of Simulated Weightlessness On the Function of Spleen Lymphocytes and the Expression of C-fos Proto-oncogene in Tail-suspended Mice]." Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, vol. 12, no. 6, 1999, pp. 423-5.
Zhang H, Hu P, Wen XL, et al. [The effect of simulated weightlessness on the function of spleen lymphocytes and the expression of c-fos proto-oncogene in tail-suspended mice]. Space Med Med Eng (Beijing). 1999;12(6):423-5.
Zhang, H., Hu, P., Wen, X. L., & Huang, B. (1999). [The effect of simulated weightlessness on the function of spleen lymphocytes and the expression of c-fos proto-oncogene in tail-suspended mice]. Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering, 12(6), 423-5.
Zhang H, et al. [The Effect of Simulated Weightlessness On the Function of Spleen Lymphocytes and the Expression of C-fos Proto-oncogene in Tail-suspended Mice]. Space Med Med Eng (Beijing). 1999;12(6):423-5. PubMed PMID: 12434808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of simulated weightlessness on the function of spleen lymphocytes and the expression of c-fos proto-oncogene in tail-suspended mice]. AU - Zhang,H, AU - Hu,P, AU - Wen,X L, AU - Huang,B, PY - 2002/11/19/pubmed PY - 2003/7/3/medline PY - 2002/11/19/entrez SP - 423 EP - 5 JF - Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering JO - Space Med Med Eng (Beijing) VL - 12 IS - 6 N2 - Objective. To investigate the effect of simulated weightlessness on proliferation of spleen lymphocyte, production of interleukin-2 and expression of c-fos proto-oncogene in mice. Method. Mice were tail-suspended for 7 or 14 days to simulate the effect of weightlessness; proliferation of lymphocyte was measured by MTT method, production of IL-2 was determined by biological activity and expression of c-fos proto-oncogene was determined by dot blotting. Result. As compared with the control, the proliferation of spleen lymphocyte and the production of IL-2 were significantly decreased in 14 d suspended group, but the expression of c-fos proto-oncogene [correction of oncogen] was increased in both 7 d and 14 d suspended groups. Conclusion. This result suggested that simulated weightlessness could interfere with the genes regulating the lymphocyte. SN - 1002-0837 UR - https://www.unboundmedicine.com/medline/citation/12434808/[The_effect_of_simulated_weightlessness_on_the_function_of_spleen_lymphocytes_and_the_expression_of_c_fos_proto_oncogene_in_tail_suspended_mice]_ DB - PRIME DP - Unbound Medicine ER -